node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cbpA | clpA | BP1011 | BP2753 | Similar to Escherichia coli curved DNA-binding protein CbpA or B1000 SW:CBPA_ECOLI (P36659) (306 aa) fasta scores: E(): 2.9e-26, 41.772% id in 316 aa, and to Caulobacter crescentus DnaJ family protein cc2772 TR:Q9A4Q8 (EMBL:AE005942) (314 aa) fasta scores: E(): 4.2e-31, 41.742% id in 333 aa. | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | 0.889 |
cbpA | clpB | BP1011 | BP1198 | Similar to Escherichia coli curved DNA-binding protein CbpA or B1000 SW:CBPA_ECOLI (P36659) (306 aa) fasta scores: E(): 2.9e-26, 41.772% id in 316 aa, and to Caulobacter crescentus DnaJ family protein cc2772 TR:Q9A4Q8 (EMBL:AE005942) (314 aa) fasta scores: E(): 4.2e-31, 41.742% id in 333 aa. | ATP-dependent protease, ATPase subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | 0.804 |
cbpA | cpn10 | BP1011 | BP3496 | Similar to Escherichia coli curved DNA-binding protein CbpA or B1000 SW:CBPA_ECOLI (P36659) (306 aa) fasta scores: E(): 2.9e-26, 41.772% id in 316 aa, and to Caulobacter crescentus DnaJ family protein cc2772 TR:Q9A4Q8 (EMBL:AE005942) (314 aa) fasta scores: E(): 4.2e-31, 41.742% id in 333 aa. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.799 |
cbpA | cpn60 | BP1011 | BP3495 | Similar to Escherichia coli curved DNA-binding protein CbpA or B1000 SW:CBPA_ECOLI (P36659) (306 aa) fasta scores: E(): 2.9e-26, 41.772% id in 316 aa, and to Caulobacter crescentus DnaJ family protein cc2772 TR:Q9A4Q8 (EMBL:AE005942) (314 aa) fasta scores: E(): 4.2e-31, 41.742% id in 333 aa. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.806 |
cbpA | dnaK | BP1011 | BP2499 | Similar to Escherichia coli curved DNA-binding protein CbpA or B1000 SW:CBPA_ECOLI (P36659) (306 aa) fasta scores: E(): 2.9e-26, 41.772% id in 316 aa, and to Caulobacter crescentus DnaJ family protein cc2772 TR:Q9A4Q8 (EMBL:AE005942) (314 aa) fasta scores: E(): 4.2e-31, 41.742% id in 333 aa. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.992 |
cbpA | grpE | BP1011 | BP2501 | Similar to Escherichia coli curved DNA-binding protein CbpA or B1000 SW:CBPA_ECOLI (P36659) (306 aa) fasta scores: E(): 2.9e-26, 41.772% id in 316 aa, and to Caulobacter crescentus DnaJ family protein cc2772 TR:Q9A4Q8 (EMBL:AE005942) (314 aa) fasta scores: E(): 4.2e-31, 41.742% id in 333 aa. | Putative GrpE chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.916 |
cbpA | hrcA | BP1011 | BP2504 | Similar to Escherichia coli curved DNA-binding protein CbpA or B1000 SW:CBPA_ECOLI (P36659) (306 aa) fasta scores: E(): 2.9e-26, 41.772% id in 316 aa, and to Caulobacter crescentus DnaJ family protein cc2772 TR:Q9A4Q8 (EMBL:AE005942) (314 aa) fasta scores: E(): 4.2e-31, 41.742% id in 333 aa. | Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.722 |
cbpA | htpG | BP1011 | BP0074 | Similar to Escherichia coli curved DNA-binding protein CbpA or B1000 SW:CBPA_ECOLI (P36659) (306 aa) fasta scores: E(): 2.9e-26, 41.772% id in 316 aa, and to Caulobacter crescentus DnaJ family protein cc2772 TR:Q9A4Q8 (EMBL:AE005942) (314 aa) fasta scores: E(): 4.2e-31, 41.742% id in 333 aa. | tRNA-Leu; Molecular chaperone. Has ATPase activity. | 0.941 |
clpA | cbpA | BP2753 | BP1011 | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | Similar to Escherichia coli curved DNA-binding protein CbpA or B1000 SW:CBPA_ECOLI (P36659) (306 aa) fasta scores: E(): 2.9e-26, 41.772% id in 316 aa, and to Caulobacter crescentus DnaJ family protein cc2772 TR:Q9A4Q8 (EMBL:AE005942) (314 aa) fasta scores: E(): 4.2e-31, 41.742% id in 333 aa. | 0.889 |
clpA | clpB | BP2753 | BP1198 | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | ATP-dependent protease, ATPase subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | 0.480 |
clpA | cpn10 | BP2753 | BP3496 | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.707 |
clpA | cpn60 | BP2753 | BP3495 | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.673 |
clpA | dnaJ | BP2753 | BP2498 | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | Molecular chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] | 0.839 |
clpA | dnaK | BP2753 | BP2499 | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.932 |
clpA | grpE | BP2753 | BP2501 | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | Putative GrpE chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.890 |
clpA | hrcA | BP2753 | BP2504 | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.767 |
clpA | htpG | BP2753 | BP0074 | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | tRNA-Leu; Molecular chaperone. Has ATPase activity. | 0.712 |
clpB | cbpA | BP1198 | BP1011 | ATP-dependent protease, ATPase subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | Similar to Escherichia coli curved DNA-binding protein CbpA or B1000 SW:CBPA_ECOLI (P36659) (306 aa) fasta scores: E(): 2.9e-26, 41.772% id in 316 aa, and to Caulobacter crescentus DnaJ family protein cc2772 TR:Q9A4Q8 (EMBL:AE005942) (314 aa) fasta scores: E(): 4.2e-31, 41.742% id in 333 aa. | 0.804 |
clpB | clpA | BP1198 | BP2753 | ATP-dependent protease, ATPase subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | Similar to Escherichia coli ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or B0882 or Z1119 or Ecs0968 SW:CLPA_ECOLI (P15716) (758 aa) fasta scores: E(): 8.5e-171, 61.73% id in 763 aa. Also similar to BP1198, 37.133% identity (46.014% ungapped) in 886 aa overlap; Belongs to the ClpA/ClpB family. | 0.480 |
clpB | cpn10 | BP1198 | BP3496 | ATP-dependent protease, ATPase subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.827 |