STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (367 aa)    
Predicted Functional Partners:
ctaB
UbiA prenyltransferase family protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
   
 
 0.976
BP2372
Putative conserved inner membrane protein; Similar to Pseudomonas aeruginosa hypothetical protein Pa0661 TR:Q9I5R0 (EMBL:AE004501) (140 aa) fasta scores: E(): 1.2e-26, 49.28% id in 140 aa, and to Neisseria meningitidis conserved hypothetical inner membrane protein NMA2177 TR:Q9JSR1 (EMBL:AL162758) (145 aa) fasta scores: E(): 6.3e-22, 45.2% id in 146 aa.
 
  
 0.934
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.925
BP3826
Putative membrane protein; Similar to Pseudomonas aeruginosa hypothetical protein PA0661 TR:Q9I5R0 (EMBL:AE004501) (140 aa) fasta scores: E(): 1.7e-05, 31.46% id in 143 aa, and to Rhizobium loti hypothetical protein MLL4486 TR:Q98DY7 (EMBL:AP003004) (162 aa) fasta scores: E(): 2.2e-05, 31.91% id in 141 aa. Possible alternative translational start site.
    
 0.917
BP0546
Bacterioferritin; Similar to Azotobacter vinelandii bacterioferritin Bfr SW:BFR_AZOVI (P22759) (156 aa) fasta scores: E(): 3.5e-05, 30.345% id in 145 aa, and to Pseudomonas aeruginosa probable bacterioferritin Pa4880 TR:Q9HUT3 (EMBL:AE004901) (177 aa) fasta scores: E(): 3.7e-41, 71.084% id in 166 aa.
   
 
 0.914
bfr
Bacterioferritin; Iron-storage protein.
     
 0.913
hrcA
Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
  
  
 0.818
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
     
 0.774
purD
Similar to Escherichia coli phosphoribosylamine--glycine ligase PurD or b4005 SW:PUR2_ECOLI (P15640) (429 aa) fasta scores: E(): 7e-93, 60.41% id in 432 aa; Belongs to the GARS family.
      
 0.718
hemF
Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
 
   
 0.708
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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