node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BP2523 | folD-2 | BP2523 | BP2522 | Putative exported protein; Similar to several proteins of undefined function e.g. Comamonas testosteroni Orf4 protein TR:Q9S155 (EMBL:AB024335) (325 aa) fasta scores: E(): 4.5e-28, 31.975% id in 319 aa. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.950 |
BP3066 | folD-2 | BP3066 | BP2522 | Similar to Pseudomonas aeruginosa 5,10-methylenetetrahydrofolate reductase MetF or PA0430 TR:Q9I687 (EMBL:AE004480) (290 aa) fasta scores: E(): 3.4e-64, 60.93% id in 279 aa, and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF SW:METF_ECOLI (EMBL:V01502) (296 aa) fasta scores: E(): 1.2e-36, 40.97% id in 266 aa. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.971 |
BP3066 | gcvT | BP3066 | BP0195 | Similar to Pseudomonas aeruginosa 5,10-methylenetetrahydrofolate reductase MetF or PA0430 TR:Q9I687 (EMBL:AE004480) (290 aa) fasta scores: E(): 3.4e-64, 60.93% id in 279 aa, and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF SW:METF_ECOLI (EMBL:V01502) (296 aa) fasta scores: E(): 1.2e-36, 40.97% id in 266 aa. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.920 |
BP3066 | glyA | BP3066 | BP2952 | Similar to Pseudomonas aeruginosa 5,10-methylenetetrahydrofolate reductase MetF or PA0430 TR:Q9I687 (EMBL:AE004480) (290 aa) fasta scores: E(): 3.4e-64, 60.93% id in 279 aa, and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF SW:METF_ECOLI (EMBL:V01502) (296 aa) fasta scores: E(): 1.2e-36, 40.97% id in 266 aa. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
BP3066 | purH | BP3066 | BP3416 | Similar to Pseudomonas aeruginosa 5,10-methylenetetrahydrofolate reductase MetF or PA0430 TR:Q9I687 (EMBL:AE004480) (290 aa) fasta scores: E(): 3.4e-64, 60.93% id in 279 aa, and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF SW:METF_ECOLI (EMBL:V01502) (296 aa) fasta scores: E(): 1.2e-36, 40.97% id in 266 aa. | Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase PurH or b4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1.4e-112, 58.11% id in 530 aa. | 0.444 |
BP3066 | thyA | BP3066 | BP3154 | Similar to Pseudomonas aeruginosa 5,10-methylenetetrahydrofolate reductase MetF or PA0430 TR:Q9I687 (EMBL:AE004480) (290 aa) fasta scores: E(): 3.4e-64, 60.93% id in 279 aa, and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF SW:METF_ECOLI (EMBL:V01502) (296 aa) fasta scores: E(): 1.2e-36, 40.97% id in 266 aa. | Putative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.934 |
fmt | folD-2 | BP0551 | BP2522 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.961 |
fmt | gcvT | BP0551 | BP0195 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.917 |
fmt | glyA | BP0551 | BP2952 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.933 |
fmt | purT | BP0551 | BP0702 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
fmt | thyA | BP0551 | BP3154 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Putative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.598 |
folD-2 | BP2523 | BP2522 | BP2523 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative exported protein; Similar to several proteins of undefined function e.g. Comamonas testosteroni Orf4 protein TR:Q9S155 (EMBL:AB024335) (325 aa) fasta scores: E(): 4.5e-28, 31.975% id in 319 aa. | 0.950 |
folD-2 | BP3066 | BP2522 | BP3066 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Similar to Pseudomonas aeruginosa 5,10-methylenetetrahydrofolate reductase MetF or PA0430 TR:Q9I687 (EMBL:AE004480) (290 aa) fasta scores: E(): 3.4e-64, 60.93% id in 279 aa, and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF SW:METF_ECOLI (EMBL:V01502) (296 aa) fasta scores: E(): 1.2e-36, 40.97% id in 266 aa. | 0.971 |
folD-2 | fmt | BP2522 | BP0551 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.961 |
folD-2 | gcvT | BP2522 | BP0195 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.941 |
folD-2 | glyA | BP2522 | BP2952 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
folD-2 | purH | BP2522 | BP3416 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase PurH or b4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1.4e-112, 58.11% id in 530 aa. | 0.962 |
folD-2 | purT | BP2522 | BP0702 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.903 |
folD-2 | purU | BP2522 | BP2514 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.914 |
folD-2 | purU-2 | BP2522 | BP3254 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.914 |