node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BP3128 | mutM | BP3128 | BP3129 | Similar to Pseudomonas aeruginosa hypothetical protein PA4667 SW:YAG7_PSEAE (P42810) (590 aa) fasta scores: E(): 9.6e-24, 28.9% id in 609 aa, and to Neisseria meningitidis putative periplasmic protein NMA1090 TR:Q9JUX9 (EMBL:AL162755) (612 aa) fasta scores: E(): 1.4e-18, 24.55% id in 619 aa. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.651 |
coaE | mutM | BP3817 | BP3129 | Putative dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.773 |
coaE | nth | BP3817 | BP3578 | Putative dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.444 |
coaE | polA | BP3817 | BP1254 | Putative dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.789 |
dnaE | mutL | BP2332 | BP0244 | Similar to many eg. Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 0, 48.89% id in 1176 aa. Its C-terminal region is also similar to BP2208, 35.149% identity (37.238% ungapped) in 606 aa overlap. | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.786 |
dnaE | mutM | BP2332 | BP3129 | Similar to many eg. Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 0, 48.89% id in 1176 aa. Its C-terminal region is also similar to BP2208, 35.149% identity (37.238% ungapped) in 606 aa overlap. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.673 |
dnaE | mutY | BP2332 | BP3836 | Similar to many eg. Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 0, 48.89% id in 1176 aa. Its C-terminal region is also similar to BP2208, 35.149% identity (37.238% ungapped) in 606 aa overlap. | Putative pyruvate ferredoxin/flavodoxin oxidoreductase (pseudogene); Adenine glycosylase active on G-A mispairs. | 0.704 |
dnaE | polA | BP2332 | BP1254 | Similar to many eg. Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 0, 48.89% id in 1176 aa. Its C-terminal region is also similar to BP2208, 35.149% identity (37.238% ungapped) in 606 aa overlap. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.709 |
dnaE | uvrB | BP2332 | BP1796 | Similar to many eg. Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 0, 48.89% id in 1176 aa. Its C-terminal region is also similar to BP2208, 35.149% identity (37.238% ungapped) in 606 aa overlap. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.728 |
dnaE | uvrC | BP2332 | BP2081 | Similar to many eg. Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 0, 48.89% id in 1176 aa. Its C-terminal region is also similar to BP2208, 35.149% identity (37.238% ungapped) in 606 aa overlap. | Putative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.768 |
dnaE | uvrD | BP2332 | BP1759 | Similar to many eg. Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 0, 48.89% id in 1176 aa. Its C-terminal region is also similar to BP2208, 35.149% identity (37.238% ungapped) in 606 aa overlap. | DNA helicase II; Similar to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 1.3e-94, 46.5% id in 772 aa, and to Neisseria meningitidis DNA helicase II Nmb0232 TR:Q9K1D0 (EMBL:AE002380) (735 aa) fasta scores: E(): 1.2e-108, 53.78% id in 766 aa. | 0.635 |
mutL | dnaE | BP0244 | BP2332 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Similar to many eg. Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 0, 48.89% id in 1176 aa. Its C-terminal region is also similar to BP2208, 35.149% identity (37.238% ungapped) in 606 aa overlap. | 0.786 |
mutL | mutM | BP0244 | BP3129 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.806 |
mutL | mutY | BP0244 | BP3836 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Putative pyruvate ferredoxin/flavodoxin oxidoreductase (pseudogene); Adenine glycosylase active on G-A mispairs. | 0.811 |
mutL | nth | BP0244 | BP3578 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.486 |
mutL | polA | BP0244 | BP1254 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.965 |
mutL | uvrB | BP0244 | BP1796 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.752 |
mutL | uvrC | BP0244 | BP2081 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Putative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.865 |
mutL | uvrD | BP0244 | BP1759 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | DNA helicase II; Similar to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 1.3e-94, 46.5% id in 772 aa, and to Neisseria meningitidis DNA helicase II Nmb0232 TR:Q9K1D0 (EMBL:AE002380) (735 aa) fasta scores: E(): 1.2e-108, 53.78% id in 766 aa. | 0.942 |
mutM | BP3128 | BP3129 | BP3128 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Similar to Pseudomonas aeruginosa hypothetical protein PA4667 SW:YAG7_PSEAE (P42810) (590 aa) fasta scores: E(): 9.6e-24, 28.9% id in 609 aa, and to Neisseria meningitidis putative periplasmic protein NMA1090 TR:Q9JUX9 (EMBL:AL162755) (612 aa) fasta scores: E(): 1.4e-18, 24.55% id in 619 aa. | 0.651 |