STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BP3271Similar to Streptomyces coelicolor putative 2-hydroxyacid dehydrogenase SCC61A.17 TR:Q9KYH6 (EMBL:AL356595) (330 aa) fasta scores: E(): 1.2e-49, 49.67% id in 308 aa, and to Bacillus subtilis D-3-phosphoglycerate dehydrogenase SerA SW:SERA_BACSU (P35136) (525 aa) fasta scores: E(): 1.4e-22, 32.48% id in 274 aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (311 aa)    
Predicted Functional Partners:
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.733
BP3268
Putative membrane-bound transglycolase; Similar to Pseudomonas aeruginosa probable membrane-bound lytic murein transglycolase A Pa1222 TR:Q9I4B6 (EMBL:AE004552) (385 aa) fasta scores: E(): 8.8e-50, 41.99% id in 381 aa, and to many from Neisseria spp. eg. Neisseria meningitidis outer membrane lipoprotein Gna33 TR:Q9JPQ9 (EMBL:AF226404) (441 aa) fasta scores: E(): 2.7e-33, 34.7% id in 461 aa, and to Escherichia coli membrane-bound lytic murein transglycosylase A precursor MltA or Mlt or b2813 or z4130 or ecs3673 SW:MLTA_ECOLI (P46885) (365 aa) fasta scores: E(): 9.1e-16, 33.11% id in 302 aa.
  
    0.605
dsbC
Putative thiol:disulphide interchange protein (periplasmic); Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process (By similarity). Necessary for extracellular secretion of the pertussis toxin (PTX); Belongs to the thioredoxin family. DsbC subfamily.
       0.601
BP3269
Putative monooxygenase; Similar to Pseudomonas aeruginosa probable FAD-dependent monooxygenase Pa5221 TR:Q9HTW9 (EMBL:AE004935) (405 aa) fasta scores: E(): 1.1e-33, 39.01% id in 387 aa, and to Escherichia coli 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase UbiF or b0662 SW:UBIF_ECOLI (P75728) (391 aa) fasta scores: E(): 2.1e-29, 34.17% id in 395 aa.
  
    0.600
apaG
Similar to Pseudomonas aeruginosa hypothetical protein Pa0591 TR:Q9I5U6 (EMBL:AE004495) (126 aa) fasta scores: E(): 9e-24, 56.19% id in 121 aa, and to Escherichia coli, and ApaA protein or b0050 or z0059 or ecs0055 SW:APAG_ECOLI (P05636) (125 aa) fasta scores: E(): 4.6e-21, 50.42% id in 117 aa.
       0.498
BP2291
Similar to Pseudomonas putida tartrate dehydrogenase SW:TTUC_PSEPU (Q51945) (364 aa) fasta scores: E(): 2.7e-99, 67.77% id in 360 aa, and to Escherichia coli probable tartrate dehydrogenase YeaU or b1800 SW:TTUC_ECOLI (P76251) (361 aa) fasta scores: E(): 7.8e-104, 69.49% id in 354 aa.
 
  
 0.493
gph
Putative phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
 
   
 0.472
aroC
Putative membrane protein (Pseudogene); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.465
thrC
Threonine synthase; Similar to Corynebacterium glutamicum threonine synthase ThrC SW:THRC_CORGL (P23669) (481 aa) fasta scores: E(): 5.5e-97, 56.56% id in 472 aa.
  
  
 0.450
nadE
Putative NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
  
 0.440
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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