node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dusB | fis | BP3414 | BP3415 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | DNA-binding protein; Similar to Escherichia coli, DNA-binding protein Fis or b3261 or z4621 or ecs4133 or stm3385 or sty3565 SW:FIS_ECOLI (P11028) (98 aa) fasta scores: E(): 1.9e-07, 40.9% id in 66 aa; Belongs to the transcriptional regulatory Fis family. | 0.992 |
dusB | purH | BP3414 | BP3416 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase PurH or b4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1.4e-112, 58.11% id in 530 aa. | 0.693 |
dusB | ruvA | BP3414 | BP3418 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.620 |
dusB | ruvC | BP3414 | BP3417 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.731 |
fis | dusB | BP3415 | BP3414 | DNA-binding protein; Similar to Escherichia coli, DNA-binding protein Fis or b3261 or z4621 or ecs4133 or stm3385 or sty3565 SW:FIS_ECOLI (P11028) (98 aa) fasta scores: E(): 1.9e-07, 40.9% id in 66 aa; Belongs to the transcriptional regulatory Fis family. | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | 0.992 |
fis | purH | BP3415 | BP3416 | DNA-binding protein; Similar to Escherichia coli, DNA-binding protein Fis or b3261 or z4621 or ecs4133 or stm3385 or sty3565 SW:FIS_ECOLI (P11028) (98 aa) fasta scores: E(): 1.9e-07, 40.9% id in 66 aa; Belongs to the transcriptional regulatory Fis family. | Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase PurH or b4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1.4e-112, 58.11% id in 530 aa. | 0.764 |
fis | ruvA | BP3415 | BP3418 | DNA-binding protein; Similar to Escherichia coli, DNA-binding protein Fis or b3261 or z4621 or ecs4133 or stm3385 or sty3565 SW:FIS_ECOLI (P11028) (98 aa) fasta scores: E(): 1.9e-07, 40.9% id in 66 aa; Belongs to the transcriptional regulatory Fis family. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.616 |
fis | ruvC | BP3415 | BP3417 | DNA-binding protein; Similar to Escherichia coli, DNA-binding protein Fis or b3261 or z4621 or ecs4133 or stm3385 or sty3565 SW:FIS_ECOLI (P11028) (98 aa) fasta scores: E(): 1.9e-07, 40.9% id in 66 aa; Belongs to the transcriptional regulatory Fis family. | Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.770 |
lexA | recG | BP1794 | BP1612 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.516 |
lexA | ruvA | BP1794 | BP3418 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.455 |
lexA | ruvC | BP1794 | BP3417 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.724 |
lexA | uvrB | BP1794 | BP1796 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.647 |
murB | ruvC | BP2510 | BP3417 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.733 |
purH | dusB | BP3416 | BP3414 | Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase PurH or b4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1.4e-112, 58.11% id in 530 aa. | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. | 0.693 |
purH | fis | BP3416 | BP3415 | Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase PurH or b4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1.4e-112, 58.11% id in 530 aa. | DNA-binding protein; Similar to Escherichia coli, DNA-binding protein Fis or b3261 or z4621 or ecs4133 or stm3385 or sty3565 SW:FIS_ECOLI (P11028) (98 aa) fasta scores: E(): 1.9e-07, 40.9% id in 66 aa; Belongs to the transcriptional regulatory Fis family. | 0.764 |
purH | ruvA | BP3416 | BP3418 | Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase PurH or b4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1.4e-112, 58.11% id in 530 aa. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.719 |
purH | ruvC | BP3416 | BP3417 | Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase PurH or b4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1.4e-112, 58.11% id in 530 aa. | Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.865 |
recG | lexA | BP1612 | BP1794 | ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.516 |
recG | rnhB | BP1612 | BP1433 | ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.410 |
recG | ruvA | BP1612 | BP3418 | ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.583 |