STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrFSimilar to Thermus aquaticus orotidine 5'-phosphate decarboxylase PyrF SW:DCOP_THETH (P96076) (241 aa) fasta scores: E(): 1e-22, 39.92% id in 258 aa, and to Halobacterium salinarum orotidine-5'-monophosphate decarboxylase VNG1673G TR:Q9P9M3 (EMBL:AF187997) (267 aa) fasta scores: E(): 2.5e-36, 44.2% id in 276 aa; Belongs to the OMP decarboxylase family. Type 2 subfamily. (273 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 
 0.999
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
 
  
 0.964
pyrC
Dihydroorotase; Similar to Pseudomonas aeruginosa dihydroorotase-like protein PyrC' or PyrX or Pa0401 SW:PYRX_PSEAE (Q51551) (423 aa) fasta scores: E(): 5.5e-50, 44.041% id in 386 aa, and to Pseudomonas putida dihydroorotase-like protein PyrC' SW:PYRX_PSEPU (Q59712) (424 aa) fasta scores: E(): 2.5e-49, 42.674% id in 389 aa.
  
  
 0.958
carB
Similar to Escherichia coli carbamoyl-phosphate synthase large chain CarB or PyrA or B0033 SW:CARB_ECOLI (P00968) (1072 aa) fasta scores: E(): 0, 68.42% id in 1080 aa, and to Neisseria meningitidis carbamoyl phosphate synthase large subunit CarB or Nma0602 TR:Q9JW02 (EMBL:AL162753) (1071 aa) fasta scores: E(): 0, 72.42% id in 1077 aa; Belongs to the CarB family.
  
  
 0.958
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
  
 
 0.948
carA
Similar to Escherichia coli carbamoyl-phosphate synthase small chain CarA or PyrA or B0032 or Z0037 or Ecs0035 SW:CARA_ECOLI (P00907) (382 aa) fasta scores: E(): 6.1e-94, 65.02% id in 366 aa, and to Pseudomonas aeruginosa carbamoyl-phosphate synthase small chain CarA or Pa4758 SW:CARA_PSEAE (P38098) (378 aa) fasta scores: E(): 7.1e-100, 68.64% id in 370 aa; Belongs to the CarA family.
  
  
 0.947
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
 
 0.937
surE
Stationary-phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.918
BP0294
Conserved hypothetical protein (Pseudogene); Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides; Belongs to the 5'(3')-deoxyribonucleotidase family.
     
  0.900
ndh
Similar to Escherichia coli NADH dehydrogenase Ndh SW:DHNA_ECOLI (P00393) (433 aa) fasta scores: E(): 1.6e-60, 43.18% id in 433 aa, and to Pseudomonas fluorescens NADH dehydrogenase II Ndh TR:Q9KGX0 (EMBL:AF281147) (432 aa) fasta scores: E(): 3.5e-68, 46.89% id in 435 aa.
  
    0.899
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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