brkA protein (Bordetella pertussis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

brkA

Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. (1010 aa)

Predicted Functional Partners:

sphB1

0.974

ptxB

0.965

tcfA

0.962

BP2924

0.962

ptxA

0.962

ptxE

0.962

ptxD

0.959

ptxC

0.955

ptlA

0.954

ptlB

0.954

Your Current Organism:

Bordetella pertussis

NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BP2924	brkA	BP2924	BP3494	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	0.962
BP2924	ptlA	BP2924	BP3788	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.	0.937
BP2924	ptlB	BP2924	BP3789	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.	0.926
BP2924	ptxA	BP2924	BP3783	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	Pertussis toxin subunit 1 precursor; S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP- binding proteins from their membrane receptors.	0.947
BP2924	ptxB	BP2924	BP3784	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	Pertussis toxin subunit 2 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.	0.956
BP2924	ptxC	BP2924	BP3787	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	Pertussis toxin subunit 3 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.	0.935
BP2924	ptxD	BP2924	BP3785	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	Pertussis toxin subunit 4 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.	0.956
BP2924	ptxE	BP2924	BP3786	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	Pertussis toxin subunit 5 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.	0.956
BP2924	sphB1	BP2924	BP0216	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	Previously sequenced as Bordetella pertussis autotransporter subtilisin-like protease SphB1 TR:CAC44081 (EMBL:AJ318229) (1039 aa) fasta scores: E(): 0, 100.000% id in 932 aa, and dimilar to Xylella fastidiosa serine protease Xf1026 TR:Q9PEK2 (EMBL:AE003939) (905 aa) fasta scores: E(): 1.1e-45, 31.919% id in 943 aa.	0.907
BP2924	tcfA	BP2924	BP1201	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	Tracheal colonization factor precursor; Identical to the previously sequenced Bordetella pertussis tracheal colonization factor precursor Tcfa2 TR:O86135 (EMBL:AJ009785) (647 aa) fasta scores: E(): 1.7e-171, 99.84% id in 647 aa.	0.948
brkA	BP2924	BP3494	BP2924	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa.	0.962
brkA	ptlA	BP3494	BP3788	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.	0.954
brkA	ptlB	BP3494	BP3789	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.	0.954
brkA	ptxA	BP3494	BP3783	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	Pertussis toxin subunit 1 precursor; S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP- binding proteins from their membrane receptors.	0.962
brkA	ptxB	BP3494	BP3784	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	Pertussis toxin subunit 2 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.	0.965
brkA	ptxC	BP3494	BP3787	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	Pertussis toxin subunit 3 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.	0.955
brkA	ptxD	BP3494	BP3785	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	Pertussis toxin subunit 4 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.	0.959
brkA	ptxE	BP3494	BP3786	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	Pertussis toxin subunit 5 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.	0.962
brkA	sphB1	BP3494	BP0216	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	Previously sequenced as Bordetella pertussis autotransporter subtilisin-like protease SphB1 TR:CAC44081 (EMBL:AJ318229) (1039 aa) fasta scores: E(): 0, 100.000% id in 932 aa, and dimilar to Xylella fastidiosa serine protease Xf1026 TR:Q9PEK2 (EMBL:AE003939) (905 aa) fasta scores: E(): 1.1e-45, 31.919% id in 943 aa.	0.974
brkA	tcfA	BP3494	BP1201	Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4.	Tracheal colonization factor precursor; Identical to the previously sequenced Bordetella pertussis tracheal colonization factor precursor Tcfa2 TR:O86135 (EMBL:AJ009785) (647 aa) fasta scores: E(): 1.7e-171, 99.84% id in 647 aa.	0.962