STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
thiGThiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (265 aa)    
Predicted Functional Partners:
BP3690
Conserved hypothetical protein; Weakly similar to Pseudomonas aeruginosa hypothetical protein PA0380 TR:Q9I6B5 (EMBL:AE004475) (66 aa) fasta scores: E(): 9.2e-10, 54.54% id in 66 aa, and to Caulobacter crescentus hypothetical protein CC1881 TR:Q9A745 (EMBL:AE005862) (66 aa) fasta scores: E(): 4.8e-09, 50% id in 66 aa.
 
 
 0.999
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.993
thiF
Adenylyltransferase; Similar to Escherichia coli adenylyltransferase ThiF or B3992 SW:THIF_ECOLI (P30138) (251 aa) fasta scores: E(): 1.1e-41, 50.000% id in 252 aa, and to Pseudomonas aeruginosa molybdopterin biosynthesis MoeB protein or Pa4663 TR:Q9HVC9 (EMBL:AE004880) (252 aa) fasta scores: E(): 5.7e-48, 54.365% id in 252 aa.
 
  
 0.987
thiD-2
Similar to Escherichia coli phosphomethylpyrimidine kinase ThiD SW:THID_ECOLI (P76422) (266 aa) fasta scores: E(): 3e-44, 51.47% id in 272 aa, and to Rhizobium meliloti phosphomethylpyrimidine kinase SMB20962 TR:CAC49487 (EMBL:AF070520) (266 aa) fasta scores: E(): 2.1e-43, 52.07% id in 265 aa. CDS contains extra residues at the N-terminus in comparison to orthologues.
 
  
 0.980
BP3809
Conserved hypothetical protein; N-terminus is similar to Proteus vulgaris mutator protein MutT SW:MUTT_PROVU (P32090) (112 aa) fasta scores: E(): 6.6e-08, 43.15% id in 95 aa, and to Xylella fastidiosa bifunctional dGTP-pyrophosphohydrolase/thiamine phosphate synthase XF1120 TR:Q9PEA8 (EMBL:AE003948) (320 aa) fasta scores: E(): 3.5e-29, 38.75% id in 320 aa; Belongs to the Nudix hydrolase family.
 
  
 0.971
thiC
Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.970
dxs
1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.933
moaD
Similar to Escherichia coli molybdopterin converting factor, subunit 1 MoaD or Chla4 or ChlM or B0784 SW:MOAD_ECOLI (P30748) (81 aa) fasta scores: E(): 4.9e-05, 46.34% id in 82 aa.
   
 
 0.828
thiD
Similar to Escherichia coli phosphomethylpyrimidine kinase ThiD or B2103 SW:THID_ECOLI (P76422) (266 aa) fasta scores: E(): 0.0004, 24.255% id in 235 aa, and to Pseudomonas aeruginosa phosphomethylpyrimidine kinase ThiD or Pa3975 TR:Q9HX41 (EMBL:AE004815) (265 aa) fasta scores: E(): 3.6e-12, 31.298% id in 262 aa.
 
  
 0.790
BP3595
Putative outer membrane protein; Similar to Salmonella typhimurium vitamin B12 receptor precursor BtuB SW:BTUB_SALTY (P37409) (614 aa) fasta scores: E(): 5.4e-37, 28.33% id in 614 aa, and to Pseudomonas aeruginosa probable tonb-dependent receptor PA1271 TR:Q9I473 (EMBL:AE004557) (616 aa) fasta scores: E(): 3.2e-39, 35.2% id in 625 aa.
  
    0.632
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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