STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)    
Predicted Functional Partners:
aceA
Putative isocitrate lyase; Similar to many e.g. Escherichia coli isocitrate lyase aceA or b4015 SW:ACEA_ECOLI (P05313) (434 aa) fasta scores: E(): 9.8e-123, 70.805% id in 435 aa.
 
 
 0.996
gltA
Putative membrane protein (pseudogene); Signal peptide predicted for BP2356 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.447 between residues 33 and 34; Belongs to the citrate synthase family.
   
 0.983
BP1352
Putative exported protein (pseudogene); Signal peptide predicted for BP1351 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.996 between residues 17 and 18.
   
 0.978
maeB-2
Similar to Escherichia coli NADP-dependent malic enzyme MaeB or B2463 SW:MAO2_ECOLI (P76558) (759 aa) fasta scores: E(): 8.6e-184, 62.13% id in 758 aa, and to Pasteurella multocida Mdh Mdh_1 or pm0002 TR:Q9CPN5 (EMBL:AE006034) (758 aa) fasta scores: E(): 5.8e-179, 62.48% id in 757 aa.
  
 
 0.974
maeB-3
Similar to Escherichia coli NADP-dependent malic enzyme MaeB SW:MAO2_ECOLI (P76558) (759 aa) fasta scores: E(): 1.6e-175, 60.07% id in 759 aa, and to Rhizobium meliloti NAD-dependent malic enzyme Dme SW:MAO1_RHIME (O30807) (770 aa) fasta scores: E(): 3.4e-169, 58.49% id in 759 aa.
  
 
 0.973
mdH
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
   
 0.966
BP2377
Putative AMP-binding protein; Similar to many predicted fatty-acid-CoA ligases eg. Rhizobium meliloti putative fatty-acid-CoA ligase protein Smc00741 TR:CAC47210 (EMBL:AL591791) (548 aa) fasta scores: E(): 2.7e-92, 45.38% id in 553 aa.
   
 0.957
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.955
BP1004
Similar to Clostridium beijerinckii phosphate butyryltransferase Ptb SW:PTB_CLOBE (Q05624) (302 aa) fasta scores: E(): 2.3e-39, 40.339% id in 295 aa, and to Rhizobium meliloti phosphate acetyltransferase Pta SW:PTA_RHIME (Q9X448) (316 aa) fasta scores: E(): 1.4e-76, 71.661% id in 307 aa.
  
 
 0.951
BP2031
Putative acyl-CoA transferase; Similar to many e.g. Pseudomonas aeruginosa coenzyme A transferase PsecoA, psecoA TR:O84911 (EMBL:AF010184) (497 aa) fasta scores: E(): 1.9e-121, 66.397% id in 494 aa.
   
 
 0.936
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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