STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisCSimilar to Escherichia coli histidinol-phosphate aminotransferase HisC SW:HIS8_ECOLI (P06986) (356 aa) fasta scores: E(): 2.3e-20, 31.4% id in 363 aa, and to Neisseria meningitidis histidinol-phosphate aminotransferase NMA1771 TR:Q9JTH8 (EMBL:AL162757) (365 aa) fasta scores: E(): 3.7e-48, 40.84% id in 355 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase; Similar to C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein hisB [includes: histidinol-phosphatase and imidazoleglycerolphosphate dehydratase] HisB SW:HIS7_ECOLI (P06987) (355 aa) fasta scores: E(): 3.6e-32, 50% id in 194 aa, and to the full length Pseudomonas aeruginosa imidazoleglycerol-phosphate dehydratase PA5143 TR:Q9HU41 (EMBL:AE004927) (197 aa) fasta scores: E(): 1.7e-56, 74.74% id in 194 aa.
 
 0.999
hisD
Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.997
tyrA
Similar to Bordetella bronchiseptica prephenate dehydrogenase TyrA TR:Q9RND8 (EMBL:AF182427) (299 aa) fasta scores: E(): 4.1e-108, 99.331% id in 299 aa, and to Rhizobium meliloti putative cyclohexadienyl dehydrogenase and adh prephenate dehydrogenase protein TR:CAC47240 (EMBL:AL591791) (307 aa) fasta scores: E(): 1.2e-33, 43.110% id in 283 aa.
  
 
 0.976
pheA
Similar to Escherichia coli P-protein [includes: chorismate mutase and prephenate dehydratase] PheA or B2599 or Z3891 or Ecs3462 SW:PHEA_ECOLI (P07022) (386 aa) fasta scores: E(): 4.9e-27, 33.773% id in 379 aa, and to Neisseria meningitidis chorismate mutase/prephenate dehydratase nmb0446 TR:Q9K0W1 (EMBL:AE002401) (362 aa) fasta scores: E(): 3.3e-66, 50.276% id in 362 aa.
 
 
 0.970
hisH
Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.954
hisG
Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.947
hisI
Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.943
hisF
Histidine biosynthesis protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.930
aspC
Similar to Rhizobium leguminosarum aspartate aminotransferase AspC or AatA SW:AAT_RHILP (O86459) (400 aa) fasta scores: E(): 3.8e-76, 51.76% id in 396 aa, and to Rhizobium meliloti aspartate aminotransferase A AatA or R02325 or smc01578 SW:AATA_RHIME (Q02635) (400 aa) fasta scores: E(): 4.4e-76, 50.75% id in 396 aa.
 
 
 0.929
BP0103
Probable class IV aminotransferase; Similar to Staphylococcus aureus D-alanine aminotransferase TR:Q9KWZ6 (EMBL:Y14816) (282 aa) fasta scores: E(): 3.7e-37, 38.849% id in 278 aa, and to Staphylococcus haemolyticus D-alanine aminotransferase Dat SW:DAAA_STAHA (P54694) (282 aa) fasta scores: E(): 1.1e-38, 38.989% id in 277 aa.
  
 
 0.920
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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