STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hisEphosphoribosyl-ATP pyrophosphohydrolase; Similar to the C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein [includes: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase] HisI SW:HIS2_ECOLI (P06989) (203 aa) fasta scores: E(): 0.0074, 32.22% id in 90 aa, and to the full length Neisseria meningitidis putative phosphoribosyl-ATP cyclohydrolase NMA0807 TR:Q9JVJ9 (EMBL:AL162754) (107 aa) fasta scores: E(): 9.6e-18, 53.77% id in 106 aa. (115 aa)    
Predicted Functional Partners:
hisG
Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
 
 0.999
hisI
Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
 0.999
hisA
Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa.
 
  
 0.998
hisF
Histidine biosynthesis protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.997
hisZ
Putative tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
 
 
 0.993
hisD
Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.993
hisB
Imidazoleglycerol-phosphate dehydratase; Similar to C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein hisB [includes: histidinol-phosphatase and imidazoleglycerolphosphate dehydratase] HisB SW:HIS7_ECOLI (P06987) (355 aa) fasta scores: E(): 3.6e-32, 50% id in 194 aa, and to the full length Pseudomonas aeruginosa imidazoleglycerol-phosphate dehydratase PA5143 TR:Q9HU41 (EMBL:AE004927) (197 aa) fasta scores: E(): 1.7e-56, 74.74% id in 194 aa.
 
  
 0.993
hisH
Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.992
hisC
Similar to Escherichia coli histidinol-phosphate aminotransferase HisC SW:HIS8_ECOLI (P06986) (356 aa) fasta scores: E(): 2.3e-20, 31.4% id in 363 aa, and to Neisseria meningitidis histidinol-phosphate aminotransferase NMA1771 TR:Q9JTH8 (EMBL:AL162757) (365 aa) fasta scores: E(): 3.7e-48, 40.84% id in 355 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.911
tatE
Sec-independent protein translocase protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
  
    0.895
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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