STRINGSTRING
ptxD protein (Bordetella pertussis) - STRING interaction network
"ptxD" - Toxin subunit 4 in Bordetella pertussis
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ptxDToxin subunit 4; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane (152 aa)    
Predicted Functional Partners:
ptxE
Toxin subunit 5; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane (133 aa)
     
 
  0.990
ptxB
Toxin subunit 2; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane (226 aa)
     
 
  0.990
ptxA
Toxin subunit 1; S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors (269 aa)
     
 
  0.980
ptxC
Toxin subunit 3; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane (227 aa)
     
 
  0.972
ptlA
Toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane (102 aa)
         
  0.555
ptlB
Toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane (104 aa)
         
  0.554
ptlD
Hypothetical protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane (463 aa)
         
  0.551
ptlG
Secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane (374 aa)
         
  0.550
ptlI
Secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane (61 aa)
         
  0.528
ptlH
Secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane (339 aa)
         
  0.527
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis, B. pertussis Tohama I, Bacterium tussis-convulsivae, Bordetella pertussis, Bordetella pertussis Tohama I, Haemophilus pertussis, Hemophilus pertussis, Microbe de la coqueluche
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