node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BP2924 | brkA | BP2924 | BP3494 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | 0.962 |
BP2924 | ptlA | BP2924 | BP3788 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. | 0.937 |
BP2924 | ptlB | BP2924 | BP3789 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. | 0.926 |
BP2924 | ptlC | BP2924 | BP3790 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | Putative bacterial secretion system protein; Component of the type IV secretion system ptl essential for secretion of assembled pertussis toxin (PTX) through the outer membrane. | 0.827 |
BP2924 | ptlI | BP2924 | BP3792 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | Putative bacterial secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. | 0.902 |
BP2924 | ptxA | BP2924 | BP3783 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | Pertussis toxin subunit 1 precursor; S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP- binding proteins from their membrane receptors. | 0.947 |
BP2924 | ptxB | BP2924 | BP3784 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | Pertussis toxin subunit 2 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. | 0.956 |
BP2924 | ptxC | BP2924 | BP3787 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | Pertussis toxin subunit 3 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. | 0.935 |
BP2924 | ptxD | BP2924 | BP3785 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | Pertussis toxin subunit 4 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. | 0.956 |
BP2924 | ptxE | BP2924 | BP3786 | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | Pertussis toxin subunit 5 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. | 0.956 |
brkA | BP2924 | BP3494 | BP2924 | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | Putative exported protein; Weakly similar to Burkholderia solanacearum probable signal peptide protein Rsp1034 TR:CAD18185 (EMBL:AL646082) (89 aa) fasta scores: E(): 2e-07, 49.33% id in 75 aa. | 0.962 |
brkA | ptlA | BP3494 | BP3788 | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. | 0.954 |
brkA | ptlB | BP3494 | BP3789 | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. | 0.954 |
brkA | ptlC | BP3494 | BP3790 | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | Putative bacterial secretion system protein; Component of the type IV secretion system ptl essential for secretion of assembled pertussis toxin (PTX) through the outer membrane. | 0.890 |
brkA | ptlI | BP3494 | BP3792 | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | Putative bacterial secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane. | 0.940 |
brkA | ptxA | BP3494 | BP3783 | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | Pertussis toxin subunit 1 precursor; S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP- binding proteins from their membrane receptors. | 0.962 |
brkA | ptxB | BP3494 | BP3784 | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | Pertussis toxin subunit 2 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. | 0.965 |
brkA | ptxC | BP3494 | BP3787 | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | Pertussis toxin subunit 3 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. | 0.955 |
brkA | ptxD | BP3494 | BP3785 | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | Pertussis toxin subunit 4 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. | 0.959 |
brkA | ptxE | BP3494 | BP3786 | Serum resistance protein; Inhibits the classical pathway of complement activation and prevents accumulation of deposited C4. | Pertussis toxin subunit 5 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. | 0.962 |