STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptxCPertussis toxin subunit 3 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane. (227 aa)    
Predicted Functional Partners:
ptxA
Pertussis toxin subunit 1 precursor; S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP- binding proteins from their membrane receptors.
  
 
 0.999
ptxB
Pertussis toxin subunit 2 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.
  
 
0.999
ptxD
Pertussis toxin subunit 4 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.
  
 
 0.999
ptxE
Pertussis toxin subunit 5 precursor; PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.
  
 
 0.999
ptlA
Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.
  
    0.984
ptlB
Pertussis toxin transport protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.
  
    0.982
ptlI
Putative bacterial secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.
  
    0.982
ptlC
Putative bacterial secretion system protein; Component of the type IV secretion system ptl essential for secretion of assembled pertussis toxin (PTX) through the outer membrane.
  
  
 0.978
ptlF
Putative bacterial secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane; Belongs to the TrbG/VirB9 family.
  
    0.970
ptlG
Putative bacterial secretion system protein; Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.
  
    0.970
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.