node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Psyc_1066 | Psyc_1067 | Psyc_1066 | Psyc_1067 | Phosphoadenylylsulfate reductase (thioredoxin). | Conserved hypothetical protein; Aligns to COG3749: Uncharacterized bacterial protein. | 0.760 |
Psyc_1066 | cysG | Psyc_1066 | Psyc_1065 | Phosphoadenylylsulfate reductase (thioredoxin). | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.982 |
Psyc_1066 | cysI | Psyc_1066 | Psyc_1068 | Phosphoadenylylsulfate reductase (thioredoxin). | Putative sulfite reductase, beta subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.997 |
Psyc_1066 | cysN | Psyc_1066 | Psyc_1069 | Phosphoadenylylsulfate reductase (thioredoxin). | Sulfate adenylyltransferase; Belongs to the sulfate adenylyltransferase family. | 0.830 |
Psyc_1067 | Psyc_1066 | Psyc_1067 | Psyc_1066 | Conserved hypothetical protein; Aligns to COG3749: Uncharacterized bacterial protein. | Phosphoadenylylsulfate reductase (thioredoxin). | 0.760 |
Psyc_1067 | cysG | Psyc_1067 | Psyc_1065 | Conserved hypothetical protein; Aligns to COG3749: Uncharacterized bacterial protein. | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.701 |
Psyc_1067 | cysI | Psyc_1067 | Psyc_1068 | Conserved hypothetical protein; Aligns to COG3749: Uncharacterized bacterial protein. | Putative sulfite reductase, beta subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.985 |
cysG | Psyc_1066 | Psyc_1065 | Psyc_1066 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Phosphoadenylylsulfate reductase (thioredoxin). | 0.982 |
cysG | Psyc_1067 | Psyc_1065 | Psyc_1067 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Conserved hypothetical protein; Aligns to COG3749: Uncharacterized bacterial protein. | 0.701 |
cysG | cysI | Psyc_1065 | Psyc_1068 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Putative sulfite reductase, beta subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.990 |
cysG | cysN | Psyc_1065 | Psyc_1069 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfate adenylyltransferase; Belongs to the sulfate adenylyltransferase family. | 0.968 |
cysG | hemA | Psyc_1065 | Psyc_0176 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.830 |
cysG | hemB | Psyc_1065 | Psyc_1578 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.915 |
cysG | hemC | Psyc_1065 | Psyc_0089 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.993 |
cysG | hemD | Psyc_1065 | Psyc_0090 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Possible uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.966 |
cysG | hemE | Psyc_1065 | Psyc_1502 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Putative uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.961 |
cysG | hemL | Psyc_1065 | Psyc_0161 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.802 |
cysI | Psyc_1066 | Psyc_1068 | Psyc_1066 | Putative sulfite reductase, beta subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Phosphoadenylylsulfate reductase (thioredoxin). | 0.997 |
cysI | Psyc_1067 | Psyc_1068 | Psyc_1067 | Putative sulfite reductase, beta subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Conserved hypothetical protein; Aligns to COG3749: Uncharacterized bacterial protein. | 0.985 |
cysI | cysG | Psyc_1068 | Psyc_1065 | Putative sulfite reductase, beta subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.990 |