node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mbur_1193 | Mbur_1194 | Mbur_1193 | Mbur_1194 | Hypothetical protein; Evidence code ER5. | Nucleotide-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.685 |
Mbur_1193 | Mbur_1195 | Mbur_1193 | Mbur_1195 | Hypothetical protein; Evidence code ER5. | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | 0.685 |
Mbur_1193 | kae1 | Mbur_1193 | Mbur_1196 | Hypothetical protein; Evidence code ER5. | Kae1-type DNA-binding protein with atypical AP endonuclease activity; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. | 0.685 |
Mbur_1194 | Mbur_1193 | Mbur_1194 | Mbur_1193 | Nucleotide-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; Evidence code ER5. | 0.685 |
Mbur_1194 | Mbur_1195 | Mbur_1194 | Mbur_1195 | Nucleotide-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | 0.813 |
Mbur_1194 | kae1 | Mbur_1194 | Mbur_1196 | Nucleotide-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Kae1-type DNA-binding protein with atypical AP endonuclease activity; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. | 0.813 |
Mbur_1195 | Mbur_1193 | Mbur_1195 | Mbur_1193 | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | Hypothetical protein; Evidence code ER5. | 0.685 |
Mbur_1195 | Mbur_1194 | Mbur_1195 | Mbur_1194 | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | Nucleotide-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.813 |
Mbur_1195 | Mbur_1355 | Mbur_1195 | Mbur_1355 | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | Protein of unknown function DUF509; Evidence code ER4. | 0.799 |
Mbur_1195 | Mbur_2146 | Mbur_1195 | Mbur_2146 | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | Thermosome subunit; Evidence code ER2; Chaperonin; Belongs to the TCP-1 chaperonin family. | 0.643 |
Mbur_1195 | eif2g | Mbur_1195 | Mbur_2278 | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | Translation initiation factor a/eIF-2 gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. | 0.606 |
Mbur_1195 | fen | Mbur_1195 | Mbur_1913 | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | FEN1 flap endonuclease with 5'-3' exonuclease activity; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the ba [...] | 0.666 |
Mbur_1195 | kae1 | Mbur_1195 | Mbur_1196 | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | Kae1-type DNA-binding protein with atypical AP endonuclease activity; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. | 0.988 |
Mbur_1195 | rpl7ae | Mbur_1195 | Mbur_0219 | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | LSU ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. | 0.674 |
Mbur_1195 | rpoD | Mbur_1195 | Mbur_0039 | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.637 |
Mbur_1195 | rps15p | Mbur_1195 | Mbur_2345 | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | SSU ribosomal protein S15P; Evidence code ER2. | 0.735 |
Mbur_1355 | Mbur_1195 | Mbur_1355 | Mbur_1195 | Protein of unknown function DUF509; Evidence code ER4. | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | 0.799 |
Mbur_1355 | kae1 | Mbur_1355 | Mbur_1196 | Protein of unknown function DUF509; Evidence code ER4. | Kae1-type DNA-binding protein with atypical AP endonuclease activity; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. | 0.796 |
Mbur_2146 | Mbur_1195 | Mbur_2146 | Mbur_1195 | Thermosome subunit; Evidence code ER2; Chaperonin; Belongs to the TCP-1 chaperonin family. | Kae1-associated Ser/Thr protein kinase; Evidence code ER2. | 0.643 |
Mbur_2146 | eif2g | Mbur_2146 | Mbur_2278 | Thermosome subunit; Evidence code ER2; Chaperonin; Belongs to the TCP-1 chaperonin family. | Translation initiation factor a/eIF-2 gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. | 0.732 |