STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLGlutamate-1-semialdehyde 2,1-aminomutase; Evidence code ER2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (422 aa)    
Predicted Functional Partners:
hemB
Delta-aminolevulinic acid dehydratase; Evidence code ER2; Porphobilinogen synthase; ALAD; ALADH; Belongs to the ALAD family.
 
 
 0.996
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.996
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 
  
 0.975
pyrD
Dihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate.
     
 0.798
pyrK
Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
     
 0.768
hemD
Uroporphyrinogen-III synthase; Evidence code ER3; UROS.
 
  
 0.742
cysGA
Uroporphyrinogen-III C-methyltransferase; Evidence code ER2; SUMT; Belongs to the precorrin methyltransferase family.
 
   
 0.710
cysGB
Siroheme synthase (Includes: Precorrin-2 dehydrogenase; Evidence code ER3.
     
 0.671
Mbur_0981
ABC transporter, permease component; Evidence code ER3.
  
  
 0.644
cbiP
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
     
 0.577
Your Current Organism:
Methanococcoides burtonii
NCBI taxonomy Id: 259564
Other names: M. burtonii DSM 6242, Methanococcoides burtonii DSM 6242, Methanococcoides burtonii str. DSM 6242
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