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cofD protein (Mycobacterium avium paratuberculosis) - STRING interaction network
"cofD" - 2-phospho-L-lactate transferase in Mycobacterium avium paratuberculosis
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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cofD2-phospho-L-lactate transferase; Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5’)guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP (343 aa)    
Predicted Functional Partners:
fbiB
Coenzyme F420-L-glutamate ligase; Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives (449 aa)
 
 
  0.998
cofC
2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5’-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (220 aa)
 
   
  0.989
fbiC
FO synthase; Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO); In the N-terminal section; belongs to the radical SAM superfamily. CofG family (867 aa)
 
 
  0.986
MAP_3377
annotation not available (177 aa)
              0.873
MAP_3376
annotation not available (526 aa)
   
        0.839
MAP_0519c
annotation not available (148 aa)
 
     
  0.797
MAP_2182c
annotation not available (144 aa)
 
     
  0.771
fgd
F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria (336 aa)
 
     
  0.759
MAP_4250c
annotation not available (347 aa)
 
     
  0.728
MAP_2679c
annotation not available (146 aa)
 
     
  0.722
Your Current Organism:
Mycobacterium avium paratuberculosis
NCBI taxonomy Id: 262316
Other names: M. avium subsp. paratuberculosis K-10, Mycobacterium avium paratuberculosis, Mycobacterium avium subsp. paratuberculosis K-10, Mycobacterium avium subsp. paratuberculosis K10, Mycobacterium avium subsp. paratuberculosis str. K-10, Mycobacterium avium subsp. paratuberculosis strain K-10
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