node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Exig_2359 | Exig_2360 | Exig_2359 | Exig_2360 | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.999 |
Exig_2359 | Exig_2365 | Exig_2359 | Exig_2365 | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | PFAM: aminotransferase class I and II; KEGG: tex:Teth514_1002 histidinol-phosphate aminotransferase. | 0.974 |
Exig_2359 | Exig_2367 | Exig_2359 | Exig_2367 | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.998 |
Exig_2359 | Exig_2368 | Exig_2359 | Exig_2368 | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | KEGG: lme:LEUM_1555 two domain histidine biosynthesis protein, ATP phosphoribosyltransferase (HisG/HisZ fusion). | 0.995 |
Exig_2359 | hisA | Exig_2359 | Exig_2362 | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: rca:Rcas_2920 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.982 |
Exig_2359 | hisB | Exig_2359 | Exig_2364 | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sgo:SGO_1407 imidazoleglycerol-phosphate dehydratase (IGPD). | 0.982 |
Exig_2359 | hisD | Exig_2359 | Exig_2366 | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.978 |
Exig_2359 | hisF | Exig_2359 | Exig_2361 | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.979 |
Exig_2359 | hisH | Exig_2359 | Exig_2363 | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.979 |
Exig_2360 | Exig_2359 | Exig_2360 | Exig_2359 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | 0.999 |
Exig_2360 | Exig_2365 | Exig_2360 | Exig_2365 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | PFAM: aminotransferase class I and II; KEGG: tex:Teth514_1002 histidinol-phosphate aminotransferase. | 0.999 |
Exig_2360 | Exig_2367 | Exig_2360 | Exig_2367 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.999 |
Exig_2360 | Exig_2368 | Exig_2360 | Exig_2368 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | KEGG: lme:LEUM_1555 two domain histidine biosynthesis protein, ATP phosphoribosyltransferase (HisG/HisZ fusion). | 0.999 |
Exig_2360 | hisA | Exig_2360 | Exig_2362 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: rca:Rcas_2920 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.999 |
Exig_2360 | hisB | Exig_2360 | Exig_2364 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sgo:SGO_1407 imidazoleglycerol-phosphate dehydratase (IGPD). | 0.999 |
Exig_2360 | hisD | Exig_2360 | Exig_2366 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
Exig_2360 | hisF | Exig_2360 | Exig_2361 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
Exig_2360 | hisH | Exig_2360 | Exig_2363 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
Exig_2360 | hisS | Exig_2360 | Exig_2087 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | KEGG: oih:OB2020 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein. | 0.564 |
Exig_2365 | Exig_2359 | Exig_2365 | Exig_2359 | PFAM: aminotransferase class I and II; KEGG: tex:Teth514_1002 histidinol-phosphate aminotransferase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lpl:lp_2552 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. | 0.974 |