STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuC3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate (472 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate
 0.999
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
 0.999
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate)
 
 0.975
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family
 
 
 0.970
TT_C0847
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family
 
 0.963
hacB
Methanogen homoaconitase small subunit; Catalyzes the reversible hydration of cis-homoaconitate ((Z)- but-1-ene-1,2,4-tricarboxylate) to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Can catalyze neither the dehydration of (R)-homocitrate ((2R)-2-hydroxybutane-1,2,4- tricarboxylate) into cis-homoaconitate in vitro, nor the reverse reaction. Is not active toward (S)-homocitrate, cis-aconitate or citrate as substrate
 
 
 0.938
hacA
3-isopropylmalate dehydratase large subunit; Catalyzes the reversible hydration of cis-homoaconitate ((Z)- but-1-ene-1,2,4-tricarboxylate) to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Can catalyze neither the dehydration of (R)-homocitrate ((2R)-2-hydroxybutane-1,2,4- tricarboxylate) into cis-homoaconitate in vitro, nor the reverse reaction. Is not active toward (S)-homocitrate, cis-aconitate or citrate as substrate
  
  
 
0.906
hicd
Homoisocitrate dehydrogenase; Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate. In addition, has high activity with citrate, but is inactive with 3-isopropylmalate
 
 0.882
TT_C1104
annotation not available
 
 
 0.868
TT_C0304
annotation not available
   
  0.863
Your Current Organism:
Thermus thermophilus HB27
NCBI taxonomy Id: 262724
Other names: T. thermophilus HB27, Thermus thermophilus str. HB27, Thermus thermophilus strain HB27
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