STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnhBRibonuclease hii; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (203 aa)    
Predicted Functional Partners:
polA
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
 
 
 0.908
TT_C1609
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for proces [...]
   
 
 0.890
TT_C1806
annotation not available
 
 
 0.819
TT_P0128
annotation not available
  
 
 0.778
rnhA
Ribonuclease hi; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids
  
 
 0.767
TT_C1789
annotation not available
       0.729
recA
Recombination protein reca; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
 
 
 0.694
metXA
Homoserine o-acetyltransferase/o-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine
      
 0.693
TT_C1786
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
  
    0.634
tmk
Probable thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
  
    0.633
Your Current Organism:
Thermus thermophilus HB27
NCBI taxonomy Id: 262724
Other names: T. thermophilus HB27, Thermus thermophilus str. HB27, Thermus thermophilus strain HB27
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