STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AAZ61411.12-oxoglutarate dehydrogenase E1 component. (950 aa)    
Predicted Functional Partners:
AAZ60676.1
Dihydrolipoamide dehydrogenase.
 
 0.999
AAZ61410.1
2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
AAZ61409.1
Dihydrolipoamide dehydrogenase.
 
 0.992
AAZ63801.1
Dihydrolipoamide dehydrogenase; FAD-dependent pyridine nucleotide-disulfide oxidoreductase:Pyridine nucleotide-disulfide oxidoreductase dimerization region.
  
 0.976
AAZ62117.1
Isocitrate dehydrogenase (NADP).
  
 
 0.970
AAZ60674.1
Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.952
AAZ64326.1
Biotin/lipoyl attachment:Catalytic domain of components of various dehydrogenase complexes:E3 binding protein.
 0.951
AAZ64897.1
Alpha/beta hydrolase fold:Biotin/lipoyl attachment.
  
 0.930
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 
 0.917
AAZ63554.1
Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family.
   
 
 0.917
Your Current Organism:
Cupriavidus pinatubonensis
NCBI taxonomy Id: 264198
Other names: C. pinatubonensis JMP134, Cupriavidus necator JMP134, Cupriavidus pinatubonensis JMP134, Ralstonia eutropha JMP134, Ralstonia eutropha str. JMP134, Ralstonia eutropha strain JMP134, Ralstonia sp. JMP134, Wautersia eutropha JMP134
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