node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aas | fabD | pc1236 | pc1719 | Similar to bifunctional AAS protein. | Similar to malonyl CoA-acyl carrier protein transacylase, fabD. | 0.993 |
aas | fabF | pc1236 | pc1238 | Similar to bifunctional AAS protein. | Probable beta-ketoacyl-ACP synthetase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | 0.986 |
aas | fabG | pc1236 | pc1156 | Similar to bifunctional AAS protein. | Similar to 3-ketoacyl-acyl carrier protein reductase, fabG. | 0.779 |
aas | fabG-2 | pc1236 | pc1718 | Similar to bifunctional AAS protein. | Probable 3-oxoacyl-[acyl-carrier protein] reductase, fabG; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.779 |
aas | fabH | pc1236 | pc1720 | Similar to bifunctional AAS protein. | Probable 3-oxoacyl-[acyl-carrier-protein] synthase III, fabH; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. | 0.847 |
aas | fabI | pc1236 | pc1152 | Similar to bifunctional AAS protein. | Strongly similar to NADH-dependent enoyl-ACP reductase. | 0.934 |
aas | fabZ | pc1236 | pc0402 | Similar to bifunctional AAS protein. | Probable myristoyl-acyl carrier dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.946 |
aas | lpxA | pc1236 | pc0403 | Similar to bifunctional AAS protein. | Probable acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine o-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.506 |
aas | lpxD | pc1236 | pc1728 | Similar to bifunctional AAS protein. | Putative UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.767 |
envA | fabZ | pc0401 | pc0402 | Putative UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | Probable myristoyl-acyl carrier dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.986 |
envA | lpxA | pc0401 | pc0403 | Putative UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | Probable acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine o-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.995 |
envA | lpxD | pc0401 | pc1728 | Putative UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | Putative UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.987 |
fabD | aas | pc1719 | pc1236 | Similar to malonyl CoA-acyl carrier protein transacylase, fabD. | Similar to bifunctional AAS protein. | 0.993 |
fabD | fabF | pc1719 | pc1238 | Similar to malonyl CoA-acyl carrier protein transacylase, fabD. | Probable beta-ketoacyl-ACP synthetase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | 0.999 |
fabD | fabG | pc1719 | pc1156 | Similar to malonyl CoA-acyl carrier protein transacylase, fabD. | Similar to 3-ketoacyl-acyl carrier protein reductase, fabG. | 0.970 |
fabD | fabG-2 | pc1719 | pc1718 | Similar to malonyl CoA-acyl carrier protein transacylase, fabD. | Probable 3-oxoacyl-[acyl-carrier protein] reductase, fabG; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.996 |
fabD | fabH | pc1719 | pc1720 | Similar to malonyl CoA-acyl carrier protein transacylase, fabD. | Probable 3-oxoacyl-[acyl-carrier-protein] synthase III, fabH; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. | 0.999 |
fabD | fabI | pc1719 | pc1152 | Similar to malonyl CoA-acyl carrier protein transacylase, fabD. | Strongly similar to NADH-dependent enoyl-ACP reductase. | 0.989 |
fabD | fabZ | pc1719 | pc0402 | Similar to malonyl CoA-acyl carrier protein transacylase, fabD. | Probable myristoyl-acyl carrier dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.961 |
fabD | lpxD | pc1719 | pc1728 | Similar to malonyl CoA-acyl carrier protein transacylase, fabD. | Putative UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.405 |