node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folD | gcvH | Bd3295 | Bd0266 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative glycine cleavage system H protein; hypothetical protein. | 0.731 |
folD | gcvH-2 | Bd3295 | Bd0683 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.761 |
folD | gcvP | Bd3295 | Bd0692 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.931 |
folD | gcvT | Bd3295 | Bd0684 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.971 |
folD | glyA | Bd3295 | Bd2007 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.982 |
folD | purD | Bd3295 | Bd3006 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylamine--glycine ligase; InterPro: Phosphoribosylglycinamide synthetase; hypothetical protein. | 0.960 |
gcvH | folD | Bd0266 | Bd3295 | Putative glycine cleavage system H protein; hypothetical protein. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.731 |
gcvH | gcvH-2 | Bd0266 | Bd0683 | Putative glycine cleavage system H protein; hypothetical protein. | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.916 |
gcvH | gcvP | Bd0266 | Bd0692 | Putative glycine cleavage system H protein; hypothetical protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
gcvH | gcvT | Bd0266 | Bd0684 | Putative glycine cleavage system H protein; hypothetical protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
gcvH | glyA | Bd0266 | Bd2007 | Putative glycine cleavage system H protein; hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.963 |
gcvH | lpdA | Bd0266 | Bd2731 | Putative glycine cleavage system H protein; hypothetical protein. | Dihydrolipoamide dehydrogenase; InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; hypothetical protein. | 0.952 |
gcvH | pdhD | Bd0266 | Bd0778 | Putative glycine cleavage system H protein; hypothetical protein. | Dihydrolipoamide dehydrogenase, E3 subunit; InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; hypothetical protein. | 0.955 |
gcvH | purD | Bd0266 | Bd3006 | Putative glycine cleavage system H protein; hypothetical protein. | Phosphoribosylamine--glycine ligase; InterPro: Phosphoribosylglycinamide synthetase; hypothetical protein. | 0.440 |
gcvH-2 | folD | Bd0683 | Bd3295 | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.761 |
gcvH-2 | gcvH | Bd0683 | Bd0266 | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Putative glycine cleavage system H protein; hypothetical protein. | 0.916 |
gcvH-2 | gcvP | Bd0683 | Bd0692 | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH-2 | gcvT | Bd0683 | Bd0684 | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH-2 | glyA | Bd0683 | Bd2007 | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
gcvH-2 | lpdA | Bd0683 | Bd2731 | Glycine cleavage system protein H homologue; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoamide dehydrogenase; InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; hypothetical protein. | 0.968 |