node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Moth_0064 | Moth_1246 | Moth_0064 | Moth_1246 | Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions. The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood- Ljungdahl pathway of re [...] | Porphobilinogen synthase; Belongs to the ALAD family. | 0.408 |
Moth_0064 | hemA | Moth_0064 | Moth_1250 | Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions. The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood- Ljungdahl pathway of re [...] | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.821 |
Moth_1096 | Moth_1248 | Moth_1096 | Moth_1248 | Cobalamin (vitamin B12) biosynthesis CbiX protein. | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase. | 0.988 |
Moth_1096 | Moth_1251 | Moth_1096 | Moth_1251 | Cobalamin (vitamin B12) biosynthesis CbiX protein. | Precorrin-2 dehydrogenase. | 0.949 |
Moth_1096 | hemA | Moth_1096 | Moth_1250 | Cobalamin (vitamin B12) biosynthesis CbiX protein. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.593 |
Moth_1246 | Moth_0064 | Moth_1246 | Moth_0064 | Porphobilinogen synthase; Belongs to the ALAD family. | Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions. The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood- Ljungdahl pathway of re [...] | 0.408 |
Moth_1246 | Moth_1248 | Moth_1246 | Moth_1248 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase. | 0.999 |
Moth_1246 | Moth_1251 | Moth_1246 | Moth_1251 | Porphobilinogen synthase; Belongs to the ALAD family. | Precorrin-2 dehydrogenase. | 0.909 |
Moth_1246 | Moth_1252 | Moth_1246 | Moth_1252 | Porphobilinogen synthase; Belongs to the ALAD family. | Trans-hexaprenyltranstransferase; Belongs to the FPP/GGPP synthase family. | 0.548 |
Moth_1246 | gltX | Moth_1246 | Moth_1132 | Porphobilinogen synthase; Belongs to the ALAD family. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.467 |
Moth_1246 | hemA | Moth_1246 | Moth_1250 | Porphobilinogen synthase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.958 |
Moth_1246 | hemC | Moth_1246 | Moth_1249 | Porphobilinogen synthase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
Moth_1246 | hemL | Moth_1246 | Moth_1244 | Porphobilinogen synthase; Belongs to the ALAD family. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.998 |
Moth_1248 | Moth_1096 | Moth_1248 | Moth_1096 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase. | Cobalamin (vitamin B12) biosynthesis CbiX protein. | 0.988 |
Moth_1248 | Moth_1246 | Moth_1248 | Moth_1246 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.999 |
Moth_1248 | Moth_1251 | Moth_1248 | Moth_1251 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase. | Precorrin-2 dehydrogenase. | 0.999 |
Moth_1248 | Moth_1252 | Moth_1248 | Moth_1252 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase. | Trans-hexaprenyltranstransferase; Belongs to the FPP/GGPP synthase family. | 0.824 |
Moth_1248 | Moth_1253 | Moth_1248 | Moth_1253 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase. | O-antigen polymerase. | 0.707 |
Moth_1248 | gltX | Moth_1248 | Moth_1132 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.629 |
Moth_1248 | hemA | Moth_1248 | Moth_1250 | uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.992 |