node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Moth_1191 | fhs | Moth_1191 | Moth_0109 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.957 |
Moth_1191 | fmt | Moth_1191 | Moth_0898 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.882 |
Moth_1191 | folD | Moth_1191 | Moth_1516 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.954 |
Moth_1191 | gcvT | Moth_1191 | Moth_1945 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.914 |
Moth_1191 | glyA | Moth_1191 | Moth_2390 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
Moth_1191 | purH | Moth_1191 | Moth_2044 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.893 |
Moth_1191 | purN | Moth_1191 | Moth_2045 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.911 |
Moth_2140 | fhs | Moth_2140 | Moth_0109 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.791 |
Moth_2140 | fmt | Moth_2140 | Moth_0898 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.656 |
Moth_2140 | folD | Moth_2140 | Moth_1516 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.918 |
Moth_2140 | purD | Moth_2140 | Moth_2043 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.481 |
Moth_2140 | purH | Moth_2140 | Moth_2044 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.550 |
Moth_2140 | purN | Moth_2140 | Moth_2045 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.769 |
fhs | Moth_1191 | Moth_0109 | Moth_1191 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.957 |
fhs | Moth_2140 | Moth_0109 | Moth_2140 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.791 |
fhs | fmt | Moth_0109 | Moth_0898 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.843 |
fhs | folD | Moth_0109 | Moth_1516 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.998 |
fhs | gcvT | Moth_0109 | Moth_1945 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.930 |
fhs | glyA | Moth_0109 | Moth_2390 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
fhs | purD | Moth_0109 | Moth_2043 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.824 |