node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Moth_2052 | Moth_2106 | Moth_2052 | Moth_2106 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.689 |
Moth_2052 | glyA | Moth_2052 | Moth_2390 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.850 |
Moth_2052 | guaA | Moth_2052 | Moth_2105 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.960 |
Moth_2052 | guaB | Moth_2052 | Moth_1108 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.936 |
Moth_2052 | purA | Moth_2052 | Moth_2309 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.998 |
Moth_2052 | purC | Moth_2052 | Moth_2051 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.999 |
Moth_2052 | purD | Moth_2052 | Moth_2043 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.986 |
Moth_2052 | purH | Moth_2052 | Moth_2044 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.998 |
Moth_2052 | pyrB | Moth_2052 | Moth_0879 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.513 |
Moth_2106 | Moth_2052 | Moth_2106 | Moth_2052 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.689 |
Moth_2106 | guaA | Moth_2106 | Moth_2105 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.992 |
Moth_2106 | guaB | Moth_2106 | Moth_1108 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.932 |
Moth_2106 | purA | Moth_2106 | Moth_2309 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.920 |
Moth_2106 | purD | Moth_2106 | Moth_2043 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.445 |
Moth_2106 | purH | Moth_2106 | Moth_2044 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.911 |
argG | guaB | Moth_2285 | Moth_1108 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.473 |
argG | purA | Moth_2285 | Moth_2309 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.896 |
argG | purH | Moth_2285 | Moth_2044 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.622 |
argG | pyrB | Moth_2285 | Moth_0879 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.857 |
glyA | Moth_2052 | Moth_2390 | Moth_2052 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.850 |