STRINGSTRING
Mfla_0191 protein (Methylobacillus flagellatus) - STRING interaction network
"Mfla_0191" - 5,10-methylenetetrahydrofolate reductase in Methylobacillus flagellatus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfla_01915,10-methylenetetrahydrofolate reductase (280 aa)    
Predicted Functional Partners:
Mfla_2509
B12-dependent methionine synthase (1262 aa)
 
 
  0.993
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (289 aa)
   
 
  0.970
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (763 aa)
 
 
  0.945
Mfla_2734
Glutamate synthase (NADPH) (1836 aa)
         
  0.941
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (430 aa)
   
 
  0.932
Mfla_0439
Aminomethyltransferase (372 aa)
   
 
  0.925
thyA1
Thymidylate synthase; Provides the sole de novo source of dTMP for DNA biosynthesis (264 aa)
     
 
  0.911
Mfla_0906
Thymidylate synthase (264 aa)
     
 
  0.911
Mfla_2076
Dihydrolipoamide dehydrogenase (588 aa)
   
 
    0.905
Mfla_1691
O-succinylhomoserine sulfhydrylase (392 aa)
   
 
  0.871
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus, M. flagellatus KT, Methylobacillus, Methylobacillus flagellatus, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
Server load: low (8%) [HD]