STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purMTIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: rso:RSc2623 phosphoribosylaminoimidazole synthetase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase category=F. (346 aa)    
Predicted Functional Partners:
purD
TIGRFAM: phosphoribosylamine--glycine ligase; PRIAM: Phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; KEGG: dar:Daro_3668 phosphoribosylglycinamide synthetase; COGs: COG0151 Phosphoribosylamine-glycine ligase category=F; Belongs to the GARS family.
  
 0.999
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
 
 0.999
Mfla_1031
TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F.
  
  
 0.999
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 0.998
purK
5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
 
 
 0.998
purC
TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PRIAM: Phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: tbd:Tbd_2668 phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase; COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase category=F.
 
  
 0.994
purH
TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein; KEGG: bma:BMA2356 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) category=F.
 
  
 0.992
purE
5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
  
 0.992
Mfla_1819
TIGRFAM: adenylosuccinate lyase; PRIAM: Adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tbd:Tbd_0518 adenylosuccinate lyase; COGs: COG0015 Adenylosuccinate lyase category=F; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.948
purT
Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
  
  
 0.944
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus KT, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
Server load: low (22%) [HD]