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topA protein (Methylobacillus flagellatus) - STRING interaction network
"topA" - DNA topoisomerase I in Methylobacillus flagellatus
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA super [...] (845 aa)    
Predicted Functional Partners:
Mfla_0358
DNA polymerase I (910 aa)
   
  0.990
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (1297 aa)
     
   
  0.963
Mfla_0887
Phosphoribosylformylglycinamidine synthase (1297 aa)
     
   
  0.963
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (344 aa)
 
  0.951
metG1
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (692 aa)
     
 
  0.950
Mfla_0921
methionyl-tRNA synthetase (692 aa)
     
 
  0.950
Mfla_0953
ATP-dependent DNA helicase RecQ (611 aa)
     
  0.948
Mfla_0953
ATP-dependent DNA helicase RecQ (611 aa)
     
  0.948
pheT
phenylalanyl-tRNA synthetase beta subunit (784 aa)
   
 
  0.947
Mfla_0317
Sulfite reductase (NADPH) alpha subunit (1383 aa)
     
   
  0.908
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus, M. flagellatus KT, Methylobacillus, Methylobacillus flagellatus, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
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