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Mfla_0558 protein (Methylobacillus flagellatus) - STRING interaction network
"Mfla_0558" - DNA topoisomerase, type I in Methylobacillus flagellatus
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second shell of interactors
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filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
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[Homology]
Score
Mfla_0558DNA topoisomerase, type I (370 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (798 aa)
     
 
  0.760
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (864 aa)
     
 
  0.760
Mfla_1422
Endonuclease/exonuclease/phosphatase (235 aa)
   
          0.593
Mfla_1426
Short-chain dehydrogenase/reductase SDR (296 aa)
 
          0.572
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA super [...] (845 aa)
     
 
  0.567
Mfla_0953
ATP-dependent DNA helicase RecQ (611 aa)
     
 
  0.546
Mfla_0953
ATP-dependent DNA helicase RecQ (611 aa)
     
 
  0.546
rnhB
RNase HII; Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (193 aa)
       
      0.476
rnhA
RNase HI; Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (151 aa)
       
      0.476
Mfla_1421
Phospholipase D/transphosphatidylase (730 aa)
   
        0.469
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus, M. flagellatus KT, Methylobacillus, Methylobacillus flagellatus, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
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