node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mfla_0807 | dnaJ | Mfla_0807 | Mfla_0750 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.423 |
Mfla_0807 | dnaK | Mfla_0807 | Mfla_0751 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.833 |
Mfla_0807 | hscB | Mfla_0807 | Mfla_0805 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.999 |
Mfla_1017 | Mfla_1170 | Mfla_1017 | Mfla_1170 | Heat shock protein Hsp90. | ATPase AAA-2; Belongs to the ClpA/ClpB family. | 0.508 |
Mfla_1017 | clpB | Mfla_1017 | Mfla_2198 | Heat shock protein Hsp90. | ATPase AAA-2; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.508 |
Mfla_1017 | dnaJ | Mfla_1017 | Mfla_0750 | Heat shock protein Hsp90. | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.973 |
Mfla_1017 | dnaK | Mfla_1017 | Mfla_0751 | Heat shock protein Hsp90. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.915 |
Mfla_1017 | groL | Mfla_1017 | Mfla_0364 | Heat shock protein Hsp90. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.882 |
Mfla_1017 | groS | Mfla_1017 | Mfla_0365 | Heat shock protein Hsp90. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.749 |
Mfla_1017 | grpE | Mfla_1017 | Mfla_0752 | Heat shock protein Hsp90. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.688 |
Mfla_1170 | Mfla_1017 | Mfla_1170 | Mfla_1017 | ATPase AAA-2; Belongs to the ClpA/ClpB family. | Heat shock protein Hsp90. | 0.508 |
Mfla_1170 | dnaJ | Mfla_1170 | Mfla_0750 | ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.787 |
Mfla_1170 | dnaK | Mfla_1170 | Mfla_0751 | ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.842 |
Mfla_1170 | groL | Mfla_1170 | Mfla_0364 | ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.538 |
Mfla_1170 | groS | Mfla_1170 | Mfla_0365 | ATPase AAA-2; Belongs to the ClpA/ClpB family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.588 |
Mfla_1170 | grpE | Mfla_1170 | Mfla_0752 | ATPase AAA-2; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.757 |
Mfla_1170 | htpG1 | Mfla_1170 | Mfla_0873 | ATPase AAA-2; Belongs to the ClpA/ClpB family. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.508 |
clpB | Mfla_1017 | Mfla_2198 | Mfla_1017 | ATPase AAA-2; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein Hsp90. | 0.508 |
clpB | dnaJ | Mfla_2198 | Mfla_0750 | ATPase AAA-2; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.787 |
clpB | dnaK | Mfla_2198 | Mfla_0751 | ATPase AAA-2; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.864 |