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smpB protein (Methylobacillus flagellatus) - STRING interaction network
"smpB" - SsrA-binding protein in Methylobacillus flagellatus
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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smpBSsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a ’tag peptide’, a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (154 aa)    
Predicted Functional Partners:
rnr
Ribonuclease R; 3’-5’ exoribonuclease that releases 5’-nucleoside monophosphates and is involved in maturation of structured RNAs (840 aa)
       
  0.921
rplS
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (129 aa)
 
   
  0.809
rpsB
30S ribosomal protein S2 (249 aa)
   
 
  0.770
rpoH
Sigma 32 (RpoH) (285 aa)
 
 
  0.756
Mfla_1143
Hypothetical protein (110 aa)
   
        0.749
Mfla_1144
Cyclase/dehydrase (145 aa)
              0.746
trmD
tRNA (Guanine37-N1) methyltransferase; Specifically methylates guanosine-37 in various tRNAs (264 aa)
 
   
  0.745
frr
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (185 aa)
 
   
  0.728
kdsA
2-dehydro-3-deoxyphosphooctonate aldolase (279 aa)
            0.704
pgk
Phosphoglycerate kinase (393 aa)
 
     
  0.692
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus, M. flagellatus KT, Methylobacillus, Methylobacillus flagellatus, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
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