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hisZ protein (Methylobacillus flagellatus) - STRING interaction network
"hisZ" - tRNA synthetase, class II (G, H, P and S) in Methylobacillus flagellatus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hisZtRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (387 aa)    
Predicted Functional Partners:
hisG
ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (214 aa)
 
  0.997
hisE
phosphoribosyl-ATP pyrophosphatase (106 aa)
 
   
  0.969
Mfla_1585
Hypothetical protein (61 aa)
   
        0.862
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (440 aa)
   
        0.856
Mfla_1587
HflK protein (391 aa)
              0.829
Mfla_1586
HflC protein; HflC and HflK could regulate a protease (294 aa)
              0.829
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of ribose 1,5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose- 5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP (311 aa)
     
 
    0.802
Mfla_1582
Flavoprotein (182 aa)
              0.785
hflX
Small GTP-binding protein domain-containing protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (375 aa)
              0.783
hfq
RNA-binding protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (81 aa)
              0.749
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus, M. flagellatus KT, Methylobacillus, Methylobacillus flagellatus, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
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