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leuB protein (Methylobacillus flagellatus) - STRING interaction network
"leuB" - 3-isopropylmalate dehydrogenase in Methylobacillus flagellatus
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second shell of interactors
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filled nodes:
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (351 aa)    
Predicted Functional Partners:
leuC
Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (468 aa)
 
  0.999
leuD
Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (214 aa)
 
  0.999
Mfla_2119
Acetolactate synthase, large subunit (568 aa)
 
  0.983
Mfla_0517
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (515 aa)
 
 
  0.981
Mfla_2734
Glutamate synthase (NADPH) (1836 aa)
   
   
  0.978
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (503 aa)
 
 
  0.969
Mfla_2120
Acetolactate synthase 3 regulatory subunit (163 aa)
 
 
  0.964
Mfla_0748
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (562 aa)
 
 
  0.948
ilvC
Ketol-acid reductoisomerase (338 aa)
 
   
  0.876
Mfla_0061
Citrate synthase (430 aa)
   
 
  0.844
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus, M. flagellatus KT, Methylobacillus, Methylobacillus flagellatus, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
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