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purU protein (Methylobacillus flagellatus) - STRING interaction network
"purU" - Formyltetrahydrofolate deformylase in Methylobacillus flagellatus
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) (296 aa)    
Predicted Functional Partners:
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (289 aa)
 
 
  0.997
Mfla_0439
Aminomethyltransferase (372 aa)
   
 
  0.948
zwf
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone (492 aa)
           
  0.941
Mfla_0917
Glucose-6-phosphate 1-dehydrogenase (492 aa)
           
  0.927
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (430 aa)
   
 
  0.925
purT
Phosphoribosylglycinamide formyltransferase 2; Catalyzes two reactions- the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP (400 aa)
         
  0.908
Mfla_2509
B12-dependent methionine synthase (1262 aa)
       
    0.905
Mfla_0914
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (167 aa)
         
    0.900
Mfla_0914
Dihydrofolate reductase (167 aa)
         
    0.900
Mfla_0722
Formate dehydrogenase subunit gamma (156 aa)
         
    0.900
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus, M. flagellatus KT, Methylobacillus, Methylobacillus flagellatus, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
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