node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mfl175 | Mfl278 | Mfl175 | Mfl278 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Guanosine-3', 5'-bis(diphosphate)3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.916 |
Mfl175 | Mfl528 | Mfl175 | Mfl528 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.910 |
Mfl175 | NrdF | Mfl175 | Mfl530 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Ribonucleoside-diphosphate reductase beta chain. | 0.913 |
Mfl175 | adk | Mfl175 | Mfl144 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.931 |
Mfl175 | gmk | Mfl175 | Mfl195 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.925 |
Mfl175 | guaA | Mfl175 | Mfl342 | Pyruvate kinase; Belongs to the pyruvate kinase family. | GMP synthase (glutamine hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.501 |
Mfl175 | guaC | Mfl175 | Mfl170 | Pyruvate kinase; Belongs to the pyruvate kinase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.503 |
Mfl196 | Mfl278 | Mfl196 | Mfl278 | tRNA and rRNA cytosine-C5-methylases; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Guanosine-3', 5'-bis(diphosphate)3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.489 |
Mfl196 | adk | Mfl196 | Mfl144 | tRNA and rRNA cytosine-C5-methylases; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.446 |
Mfl196 | gmk | Mfl196 | Mfl195 | tRNA and rRNA cytosine-C5-methylases; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.919 |
Mfl196 | guaA | Mfl196 | Mfl342 | tRNA and rRNA cytosine-C5-methylases; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | GMP synthase (glutamine hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.466 |
Mfl196 | guaC | Mfl196 | Mfl170 | tRNA and rRNA cytosine-C5-methylases; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.453 |
Mfl278 | Mfl175 | Mfl278 | Mfl175 | Guanosine-3', 5'-bis(diphosphate)3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.916 |
Mfl278 | Mfl196 | Mfl278 | Mfl196 | Guanosine-3', 5'-bis(diphosphate)3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | tRNA and rRNA cytosine-C5-methylases; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.489 |
Mfl278 | Mfl528 | Mfl278 | Mfl528 | Guanosine-3', 5'-bis(diphosphate)3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.907 |
Mfl278 | NrdF | Mfl278 | Mfl530 | Guanosine-3', 5'-bis(diphosphate)3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Ribonucleoside-diphosphate reductase beta chain. | 0.900 |
Mfl278 | apt | Mfl278 | Mfl276 | Guanosine-3', 5'-bis(diphosphate)3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.576 |
Mfl278 | gmk | Mfl278 | Mfl195 | Guanosine-3', 5'-bis(diphosphate)3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.934 |
Mfl463 | adk | Mfl463 | Mfl144 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.828 |
Mfl463 | apt | Mfl463 | Mfl276 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.946 |