node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mfl042 | Mfl060 | Mfl042 | Mfl060 | Dihydrolipate dehydrogenase. | Putative folyl-polyglutamate synthetase. | 0.531 |
Mfl042 | Mfl383 | Mfl042 | Mfl383 | Dihydrolipate dehydrogenase. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.657 |
Mfl042 | folD | Mfl042 | Mfl167 | Dihydrolipate dehydrogenase. | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.769 |
Mfl042 | glyA | Mfl042 | Mfl106 | Dihydrolipate dehydrogenase. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.961 |
Mfl042 | purA | Mfl042 | Mfl074 | Dihydrolipate dehydrogenase. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.520 |
Mfl042 | thyA | Mfl042 | Mfl419 | Dihydrolipate dehydrogenase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.739 |
Mfl060 | Mfl042 | Mfl060 | Mfl042 | Putative folyl-polyglutamate synthetase. | Dihydrolipate dehydrogenase. | 0.531 |
Mfl060 | Mfl383 | Mfl060 | Mfl383 | Putative folyl-polyglutamate synthetase. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.923 |
Mfl060 | glyA | Mfl060 | Mfl106 | Putative folyl-polyglutamate synthetase. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.733 |
Mfl060 | thyA | Mfl060 | Mfl419 | Putative folyl-polyglutamate synthetase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.845 |
Mfl383 | Mfl042 | Mfl383 | Mfl042 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Dihydrolipate dehydrogenase. | 0.657 |
Mfl383 | Mfl060 | Mfl383 | Mfl060 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Putative folyl-polyglutamate synthetase. | 0.923 |
Mfl383 | Mfl385 | Mfl383 | Mfl385 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Deoxycytidylate deaminase. | 0.717 |
Mfl383 | glyA | Mfl383 | Mfl106 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.940 |
Mfl383 | tdk | Mfl383 | Mfl635 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidine, deoxyuridine kinase. | 0.423 |
Mfl383 | thyA | Mfl383 | Mfl419 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.962 |
Mfl383 | tmk | Mfl383 | Mfl676 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.774 |
Mfl385 | Mfl383 | Mfl385 | Mfl383 | Deoxycytidylate deaminase. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.717 |
Mfl385 | tdk | Mfl385 | Mfl635 | Deoxycytidylate deaminase. | Thymidine, deoxyuridine kinase. | 0.934 |
Mfl385 | thyA | Mfl385 | Mfl419 | Deoxycytidylate deaminase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.942 |