node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rxyl_0650 | hisA | Rxyl_0650 | Rxyl_1105 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase, putative; PFAM: aminotransferase, class I and II; KEGG: det:DET0689 histidinol-phosphate aminotransferase, putative. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mta:Moth_2032 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.903 |
Rxyl_0650 | hisB | Rxyl_0650 | Rxyl_1103 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase, putative; PFAM: aminotransferase, class I and II; KEGG: det:DET0689 histidinol-phosphate aminotransferase, putative. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gox:GOX0479 imidazoleglycerol-phosphate dehydratase. | 0.998 |
Rxyl_0650 | hisD | Rxyl_0650 | Rxyl_1102 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase, putative; PFAM: aminotransferase, class I and II; KEGG: det:DET0689 histidinol-phosphate aminotransferase, putative. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.989 |
Rxyl_0650 | hisF | Rxyl_0650 | Rxyl_2117 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase, putative; PFAM: aminotransferase, class I and II; KEGG: det:DET0689 histidinol-phosphate aminotransferase, putative. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.895 |
Rxyl_0650 | hisG | Rxyl_0650 | Rxyl_1101 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase, putative; PFAM: aminotransferase, class I and II; KEGG: det:DET0689 histidinol-phosphate aminotransferase, putative. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.891 |
Rxyl_0650 | hisH | Rxyl_0650 | Rxyl_1104 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase, putative; PFAM: aminotransferase, class I and II; KEGG: det:DET0689 histidinol-phosphate aminotransferase, putative. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.987 |
Rxyl_0650 | hisI | Rxyl_0650 | Rxyl_2116 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase, putative; PFAM: aminotransferase, class I and II; KEGG: det:DET0689 histidinol-phosphate aminotransferase, putative. | PFAM: phosphoribosyl-AMP cyclohydrolase phosphoribosyl-ATP pyrophosphohydrolase; KEGG: bha:BH3577 phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.988 |
guaA | hisA | Rxyl_0816 | Rxyl_1105 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mta:Moth_2032 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.818 |
guaA | hisB | Rxyl_0816 | Rxyl_1103 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gox:GOX0479 imidazoleglycerol-phosphate dehydratase. | 0.434 |
guaA | hisF | Rxyl_0816 | Rxyl_2117 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.502 |
guaA | hisH | Rxyl_0816 | Rxyl_1104 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.541 |
guaA | hisI | Rxyl_0816 | Rxyl_2116 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | PFAM: phosphoribosyl-AMP cyclohydrolase phosphoribosyl-ATP pyrophosphohydrolase; KEGG: bha:BH3577 phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.516 |
guaA | hisZ | Rxyl_0816 | Rxyl_1100 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.600 |
hisA | Rxyl_0650 | Rxyl_1105 | Rxyl_0650 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mta:Moth_2032 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: L-threonine-O-3-phosphate decarboxylase, putative; PFAM: aminotransferase, class I and II; KEGG: det:DET0689 histidinol-phosphate aminotransferase, putative. | 0.903 |
hisA | guaA | Rxyl_1105 | Rxyl_0816 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mta:Moth_2032 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.818 |
hisA | hisB | Rxyl_1105 | Rxyl_1103 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mta:Moth_2032 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gox:GOX0479 imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC | Rxyl_1105 | Rxyl_0726 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mta:Moth_2032 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: chy:CHY_1929 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.853 |
hisA | hisD | Rxyl_1105 | Rxyl_1102 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mta:Moth_2032 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisF | Rxyl_1105 | Rxyl_2117 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mta:Moth_2032 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Rxyl_1105 | Rxyl_1101 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mta:Moth_2032 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.998 |