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folD2 protein (Rubrobacter xylanophilus) - STRING interaction network
"folD2" - Bifunctional protein FolD 2 in Rubrobacter xylanophilus
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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folD2Bifunctional protein FolD 2; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (320 aa)    
Predicted Functional Partners:
fhs2
Formate--tetrahydrofolate ligase 2; PFAM- formate-tetrahydrofolate ligase, FTHFS; KEGG- pac-PPA0049 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family (576 aa)
 
 
  0.989
purH
Bifunctional purine biosynthesis protein PurH; KEGG- tfu-Tfu_2572 AICARFT/IMPCHase bienzyme; TIGRFAM- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- AICARFT/IMPCHase bienzyme MGS-like (507 aa)
 
  0.961
Rxyl_0843
PFAM- methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG- pca-Pcar_0238 methylenetetrahydrofolate reductase family protein (611 aa)
   
 
  0.960
Rxyl_1649
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (434 aa)
 
 
  0.959
Rxyl_0469
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (474 aa)
 
 
  0.958
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (194 aa)
 
 
  0.956
Rxyl_0209
PFAM- glycine cleavage T protein (aminomethyl transferase); KEGG- nar-Saro_2861 vanillate/3-O-methylgallate O-demethylase; Belongs to the GcvT family (450 aa)
 
 
  0.941
Rxyl_0192
PFAM- glycine cleavage T protein (aminomethyl transferase); KEGG- nar-Saro_2404 glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family (462 aa)
 
 
  0.941
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus (306 aa)
 
 
  0.938
fhs3
Formate--tetrahydrofolate ligase 3; PFAM- formate-tetrahydrofolate ligase, FTHFS; KEGG- pac-PPA0049 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family (573 aa)
 
 
  0.931
Your Current Organism:
Rubrobacter xylanophilus
NCBI taxonomy Id: 266117
Other names: R. xylanophilus DSM 9941, Rubrobacter xylanophilus, Rubrobacter xylanophilus DSM 9941, Rubrobacter xylanophilus DSM9941, Rubrobacter xylanophilus str. DSM 9941, Rubrobacter xylanophilus strain DSM 9941
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