node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rxyl_0470 | Rxyl_0843 | Rxyl_0470 | Rxyl_0843 | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. | 0.927 |
Rxyl_0470 | Rxyl_1567 | Rxyl_0470 | Rxyl_1567 | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mca:MCA0507 methenyltetrahydrofolate cyclohydrolase. | 0.911 |
Rxyl_0470 | fhs2 | Rxyl_0470 | Rxyl_1568 | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: pac:PPA0049 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.920 |
Rxyl_0470 | folD1 | Rxyl_0470 | Rxyl_0827 | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.926 |
Rxyl_0470 | folD2 | Rxyl_0470 | Rxyl_1566 | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.926 |
Rxyl_0470 | folD3 | Rxyl_0470 | Rxyl_2517 | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.926 |
Rxyl_0470 | glyA | Rxyl_0470 | Rxyl_0469 | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.973 |
Rxyl_0470 | glyA-2 | Rxyl_0470 | Rxyl_1649 | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
Rxyl_0470 | purH | Rxyl_0470 | Rxyl_1000 | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | KEGG: tfu:Tfu_2572 AICARFT/IMPCHase bienzyme; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like. | 0.919 |
Rxyl_0470 | purN | Rxyl_0470 | Rxyl_0999 | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.913 |
Rxyl_0843 | Rxyl_0470 | Rxyl_0843 | Rxyl_0470 | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.927 |
Rxyl_0843 | fhs2 | Rxyl_0843 | Rxyl_1568 | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: pac:PPA0049 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.941 |
Rxyl_0843 | folD1 | Rxyl_0843 | Rxyl_0827 | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.938 |
Rxyl_0843 | folD2 | Rxyl_0843 | Rxyl_1566 | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.938 |
Rxyl_0843 | folD3 | Rxyl_0843 | Rxyl_2517 | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.938 |
Rxyl_0843 | glyA | Rxyl_0843 | Rxyl_0469 | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.947 |
Rxyl_0843 | glyA-2 | Rxyl_0843 | Rxyl_1649 | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.947 |
Rxyl_0843 | purH | Rxyl_0843 | Rxyl_1000 | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. | KEGG: tfu:Tfu_2572 AICARFT/IMPCHase bienzyme; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like. | 0.937 |
Rxyl_0843 | purN | Rxyl_0843 | Rxyl_0999 | PFAM: methylenetetrahydrofolate reductase homocysteine S-methyltransferase; KEGG: pca:Pcar_0238 methylenetetrahydrofolate reductase family protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.943 |
Rxyl_1567 | Rxyl_0470 | Rxyl_1567 | Rxyl_0470 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mca:MCA0507 methenyltetrahydrofolate cyclohydrolase. | KEGG: mlo:mlr4790 aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.911 |