STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hutHHistidine ammonia-lyase (Histidase); Has ammonia-lyase and, to a lesser extent, aminomutase activity. Catalyzes the rearrangement of L-tyrosine to R-beta-tyrosine and S-beta-tyrosine. Does not accept L-histidine or L-phenylalanine as substrates; Belongs to the TAL/TAM family. (533 aa)    
Predicted Functional Partners:
hutU1
Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.
 
 0.980
hutI
Imidazolonepropionase; Belongs to the metallo-dependent hydrolases superfamily. HutI family.
 
  
 0.957
hisC1
Histidinol-phosphate transaminase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 
 0.909
hisC
Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
    
 0.909
tyrB
Tyrosine aminotransferase, tyrosine-repressible, PLP-dependent.
   
 
 0.902
phhA
Phenylalanine-4-hydroxylase (PAH) (Phe-4- monooxygenase).
   
 
 0.830
hutF
Formiminoglutamate deiminase.
 
  
 0.755
hutG
N-Formylglutamate amidohydrolase.
  
  
 0.701
matB
Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.
  
  
 0.612
gcvP
Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.524
Your Current Organism:
Cupriavidus metallidurans
NCBI taxonomy Id: 266264
Other names: C. metallidurans CH34, Cupriavidus metallidurans CH34, Cupriavidus metallidurans str. CH34, Cupriavidus metallidurans strain CH34, Ralstonia metallidurans CH34, Wautersia metallidurans CH34
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.