node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rmet_1427 | ftsA | Rmet_1427 | Rmet_3124 | Conserved hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | 0.444 |
Rmet_1427 | ftsQ | Rmet_1427 | Rmet_3125 | Conserved hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.720 |
Rmet_1427 | ftsZ | Rmet_1427 | Rmet_3123 | Conserved hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | GTP-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.917 |
ftsA | Rmet_1427 | Rmet_3124 | Rmet_1427 | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Conserved hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | 0.444 |
ftsA | ftsI | Rmet_3124 | Rmet_3134 | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | 0.936 |
ftsA | ftsQ | Rmet_3124 | Rmet_3125 | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.996 |
ftsA | ftsW | Rmet_3124 | Rmet_3129 | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Integral membrane protein involved in stabilizing FstZ ring during cell division; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.969 |
ftsA | ftsZ | Rmet_3124 | Rmet_3123 | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | GTP-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.999 |
ftsA | minC | Rmet_3124 | Rmet_0035 | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division inhibitor MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. | 0.420 |
ftsA | murC | Rmet_3124 | Rmet_3127 | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | UDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.929 |
ftsA | murE | Rmet_3124 | Rmet_3133 | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.806 |
ftsA | murF | Rmet_3124 | Rmet_3132 | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.813 |
ftsA | murG | Rmet_3124 | Rmet_3128 | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | N-acetylglucosaminyl transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.912 |
ftsI | ftsA | Rmet_3134 | Rmet_3124 | Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | 0.936 |
ftsI | ftsQ | Rmet_3134 | Rmet_3125 | Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.967 |
ftsI | ftsW | Rmet_3134 | Rmet_3129 | Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | Integral membrane protein involved in stabilizing FstZ ring during cell division; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.989 |
ftsI | ftsZ | Rmet_3134 | Rmet_3123 | Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | GTP-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.804 |
ftsI | murC | Rmet_3134 | Rmet_3127 | Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | UDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.901 |
ftsI | murE | Rmet_3134 | Rmet_3133 | Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.973 |
ftsI | murF | Rmet_3134 | Rmet_3132 | Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. | UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.940 |