STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bphI4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of both 4-hydroxy-2- oxopentanoate (HOPA) and 4-hydroxy-2-oxohexanoate (HOHA) to pyruvate and acetaldehyde or propanaldehyde, respectively. The aldehydes produced by this reaction are directly channeled from BphI to the dehydrogenase BphJ, ensuring that these toxic aldehydes are sequestered from cellular components. Is involved in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs). Appears to be stereospecific since it can cleave (4S)-4-hydroxy-2-oxopentanoate but not the (4R) isomer. Al [...] (346 aa)    
Predicted Functional Partners:
bphJ
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde or propanal to acetyl-CoA or propanoyl-CoA, respectively, using NAD(+) and coenzyme A. Displays broad specificity since it can utilize aliphatic aldehydes from two to five carbons in length as substrates; the aldehyde substrates can be directly channeled from the aldolase BphI to the dehydrogenase BphJ. Is the final enzyme in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs). Is also able to utilize NADP(+) instead of NAD(+). Is not active with succinic semialdehyde or picolinaldehyde a [...]
 0.998
bphH
2-hydroxypenta-2,4-dienoate hydratase (BphH); Biphenyl pathway; Citation: J. Bacteriol. 174 (9), 2903-2912 (1992). Gene 144 (1), 9-16 (1994).
 
 
 0.994
amnH
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 0.987
Bxe_A3547
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 0.987
Bxe_B2326
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 0.987
Bxe_B2327
Putative 2-hydroxypenta-2,4-dienoate hydratase(MhpD); 3-hydroxyphenyl propionate pathway; Citation: Microbiology 145 (Pt 10), 2813-2820(1999).
 
 
 0.952
amnF
2-keto-4-pentenoate hydratase; Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid. Belongs to the hydratase/decarboxylase family. MhpD subfamily.
 
 
 0.950
Bxe_A3548
2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996).
 
 
 0.927
bphD
2-hydroxy-6-oxo-6-phenylhexa-2,4- dienoate hydrolase (BphD); Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo- 6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2- hydroxy-2,4-pentadienoic acid (HPD); Belongs to the AB hydrolase superfamily. BphD family.
 
 
 0.921
Bxe_A3959
Para-aminobenzoate synthase, component I.
  
 0.874
Your Current Organism:
Paraburkholderia xenovorans
NCBI taxonomy Id: 266265
Other names: Burkholderia cepacia LB400, Burkholderia fungorum LB400, Burkholderia sp. LB400, Burkholderia xenovorans LB400, P. xenovorans LB400, Paraburkholderia xenovorans LB400, Pseudomonas LB400, Pseudomonas sp. (strain LB400), Pseudomonas sp. LB400
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