node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bxe_A3546 | Bxe_A3548 | Bxe_A3546 | Bxe_A3548 | 4-hydroxy-2-ketovalerate aldolase (CmtG); Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996). | 0.977 |
Bxe_A3546 | Bxe_B2327 | Bxe_A3546 | Bxe_B2327 | 4-hydroxy-2-ketovalerate aldolase (CmtG); Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Putative 2-hydroxypenta-2,4-dienoate hydratase(MhpD); 3-hydroxyphenyl propionate pathway; Citation: Microbiology 145 (Pt 10), 2813-2820(1999). | 0.951 |
Bxe_A3546 | bphD | Bxe_A3546 | Bxe_C1186 | 4-hydroxy-2-ketovalerate aldolase (CmtG); Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 2-hydroxy-6-oxo-6-phenylhexa-2,4- dienoate hydrolase (BphD); Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo- 6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2- hydroxy-2,4-pentadienoic acid (HPD); Belongs to the AB hydrolase superfamily. BphD family. | 0.716 |
Bxe_A3546 | bphH | Bxe_A3546 | Bxe_C1189 | 4-hydroxy-2-ketovalerate aldolase (CmtG); Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 2-hydroxypenta-2,4-dienoate hydratase (BphH); Biphenyl pathway; Citation: J. Bacteriol. 174 (9), 2903-2912 (1992). Gene 144 (1), 9-16 (1994). | 0.964 |
Bxe_A3546 | bphI | Bxe_A3546 | Bxe_C1187 | 4-hydroxy-2-ketovalerate aldolase (CmtG); Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of both 4-hydroxy-2- oxopentanoate (HOPA) and 4-hydroxy-2-oxohexanoate (HOHA) to pyruvate and acetaldehyde or propanaldehyde, respectively. The aldehydes produced by this reaction are directly channeled from BphI to the dehydrogenase BphJ, ensuring that these toxic aldehydes are sequestered from cellular components. Is involved in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs). Appears to be stereospecific since it can cleave (4S)-4-hydroxy-2-oxopentanoate but not the (4R) isomer. Al [...] | 0.523 |
Bxe_A3546 | bphJ | Bxe_A3546 | Bxe_C1188 | 4-hydroxy-2-ketovalerate aldolase (CmtG); Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde or propanal to acetyl-CoA or propanoyl-CoA, respectively, using NAD(+) and coenzyme A. Displays broad specificity since it can utilize aliphatic aldehydes from two to five carbons in length as substrates; the aldehyde substrates can be directly channeled from the aldolase BphI to the dehydrogenase BphJ. Is the final enzyme in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs). Is also able to utilize NADP(+) instead of NAD(+). Is not active with succinic semialdehyde or picolinaldehyde a [...] | 0.986 |
Bxe_A3548 | Bxe_A3546 | Bxe_A3548 | Bxe_A3546 | 2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996). | 4-hydroxy-2-ketovalerate aldolase (CmtG); Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.977 |
Bxe_A3548 | Bxe_B2325 | Bxe_A3548 | Bxe_B2325 | 2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996). | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.927 |
Bxe_A3548 | amnG | Bxe_A3548 | Bxe_A1152 | 2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996). | 4-hydroxy 2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.928 |
Bxe_A3548 | bphD | Bxe_A3548 | Bxe_C1186 | 2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996). | 2-hydroxy-6-oxo-6-phenylhexa-2,4- dienoate hydrolase (BphD); Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo- 6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2- hydroxy-2,4-pentadienoic acid (HPD); Belongs to the AB hydrolase superfamily. BphD family. | 0.801 |
Bxe_A3548 | bphI | Bxe_A3548 | Bxe_C1187 | 2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996). | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of both 4-hydroxy-2- oxopentanoate (HOPA) and 4-hydroxy-2-oxohexanoate (HOHA) to pyruvate and acetaldehyde or propanaldehyde, respectively. The aldehydes produced by this reaction are directly channeled from BphI to the dehydrogenase BphJ, ensuring that these toxic aldehydes are sequestered from cellular components. Is involved in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs). Appears to be stereospecific since it can cleave (4S)-4-hydroxy-2-oxopentanoate but not the (4R) isomer. Al [...] | 0.927 |
Bxe_A3548 | bphJ | Bxe_A3548 | Bxe_C1188 | 2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996). | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde or propanal to acetyl-CoA or propanoyl-CoA, respectively, using NAD(+) and coenzyme A. Displays broad specificity since it can utilize aliphatic aldehydes from two to five carbons in length as substrates; the aldehyde substrates can be directly channeled from the aldolase BphI to the dehydrogenase BphJ. Is the final enzyme in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs). Is also able to utilize NADP(+) instead of NAD(+). Is not active with succinic semialdehyde or picolinaldehyde a [...] | 0.890 |
Bxe_A3548 | leuA | Bxe_A3548 | Bxe_A1435 | 2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996). | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.429 |
Bxe_A3548 | leuA-2 | Bxe_A3548 | Bxe_A3225 | 2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996). | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.429 |
Bxe_B2325 | Bxe_A3548 | Bxe_B2325 | Bxe_A3548 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 2-hydroxypenta-2,4-dienoate hydratase (CmtF); P-cumate pathway; Citation: J. Bacteriol. 178 (5), 1351-1362 (1996). | 0.927 |
Bxe_B2325 | Bxe_B2327 | Bxe_B2325 | Bxe_B2327 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Putative 2-hydroxypenta-2,4-dienoate hydratase(MhpD); 3-hydroxyphenyl propionate pathway; Citation: Microbiology 145 (Pt 10), 2813-2820(1999). | 0.983 |
Bxe_B2325 | bphD | Bxe_B2325 | Bxe_C1186 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 2-hydroxy-6-oxo-6-phenylhexa-2,4- dienoate hydrolase (BphD); Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo- 6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2- hydroxy-2,4-pentadienoic acid (HPD); Belongs to the AB hydrolase superfamily. BphD family. | 0.729 |
Bxe_B2325 | bphH | Bxe_B2325 | Bxe_C1189 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 2-hydroxypenta-2,4-dienoate hydratase (BphH); Biphenyl pathway; Citation: J. Bacteriol. 174 (9), 2903-2912 (1992). Gene 144 (1), 9-16 (1994). | 0.964 |
Bxe_B2325 | bphI | Bxe_B2325 | Bxe_C1187 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of both 4-hydroxy-2- oxopentanoate (HOPA) and 4-hydroxy-2-oxohexanoate (HOHA) to pyruvate and acetaldehyde or propanaldehyde, respectively. The aldehydes produced by this reaction are directly channeled from BphI to the dehydrogenase BphJ, ensuring that these toxic aldehydes are sequestered from cellular components. Is involved in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs). Appears to be stereospecific since it can cleave (4S)-4-hydroxy-2-oxopentanoate but not the (4R) isomer. Al [...] | 0.524 |
Bxe_B2325 | bphJ | Bxe_B2325 | Bxe_C1188 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde or propanal to acetyl-CoA or propanoyl-CoA, respectively, using NAD(+) and coenzyme A. Displays broad specificity since it can utilize aliphatic aldehydes from two to five carbons in length as substrates; the aldehyde substrates can be directly channeled from the aldolase BphI to the dehydrogenase BphJ. Is the final enzyme in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs). Is also able to utilize NADP(+) instead of NAD(+). Is not active with succinic semialdehyde or picolinaldehyde a [...] | 0.987 |