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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
bphBCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase; Biphenyl pathway; Citation: J. Bacteriol. 174 (9), 2903-2912 (1992); Belongs to the short-chain dehydrogenases/reductases (SDR) family (277 aa)    
Predicted Functional Partners:
bphC
Biphenyl-2,3-diol 1,2-dioxygenase; Shows a preference for catechols with groups immediately adjacent to the hydroxyl substituents; Belongs to the extradiol ring-cleavage dioxygenase family
 
 0.996
bphA2
Biphenyl dioxygenase subunit beta; The beta subunit may be responsible for the substrate specificity of the enzyme; Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family
 
 
 0.993
bphA1
Biphenyl dioxygenase subunit alpha; Biphenyl pathway; Citation: J. Bacteriol. 174 (9), 2903-2912 (1992)
 
  
 0.991
bphA3
Biphenyl dioxygenase system ferredoxin subunit; This protein seems to be a 2Fe-2S ferredoxin
 
 
 0.988
bphA4
Biphenyl dioxygenase system ferredoxin--NAD(+) reductase component; Part of the electron transfer component of biphenyl dioxygenase, transfers electrons from ferredoxin (BphF) to NADH
 
  
 0.986
Bxe_C0640
Aromatic ring-cleavage dioxygenase; Citation: J. Bacteriol. 182:3784-3793(2000)
 
 0.942
bphD
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6- oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD); Belongs to the AB hydrolase superfamily. BphD family
 
 
 0.869
bphJ
Acetaldehyde dehydrogenase 4; Catalyzes the conversion of acetaldehyde or propanal to acetyl-CoA or propanoyl-CoA, respectively, using NAD(+) and coenzyme A. Displays broad specificity since it can utilize aliphatic aldehydes from two to five carbons in length as substrates; the aldehyde substrates can be directly channeled from the aldolase BphI to the dehydrogenase BphJ. Is the final enzyme in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs). Is also able to utilize NADP(+) instead of NAD(+). Is not active with succinic semialdehyde or picolinaldehyde [...]
 
   
 0.785
bphK
Glutathione S-transferase (BphK); Biphenyl pathway; Citation: J. Bacteriol. 174 (9), 2903-2912 (1992). Gene 144 (1), 9-16 (1994)
  
 
 0.785
bphI
4-hydroxy-2-oxovalerate aldolase 4; Catalyzes the retro-aldol cleavage of both 4-hydroxy-2- oxopentanoate (HOPA) and 4-hydroxy-2-oxohexanoate (HOHA) to pyruvate and acetaldehyde or propanaldehyde, respectively. The aldehydes produced by this reaction are directly channeled from BphI to the dehydrogenase BphJ, ensuring that these toxic aldehydes are sequestered from cellular components. Is involved in the meta-cleavage pathway for the degradation of polychlorinated biphenyls (PCBs). Appears to be stereospecific since it can cleave (4S)-4-hydroxy-2-oxopentanoate but not the (4R) isomer. [...]
 
   
 0.779
Your Current Organism:
Burkholderia xenovorans
NCBI taxonomy Id: 266265
Other names: B. xenovorans LB400, Burkholderia cepacia LB400, Burkholderia fungorum LB400, Burkholderia sp. LB400, Burkholderia xenovorans, Burkholderia xenovorans LB400, Burkholderia xenovorans str. LB400, Burkholderia xenovorans strain LB400, Pseudomonas LB400, Pseudomonas sp. (strain LB400), Pseudomonas sp. LB400
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