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bluB protein (Sinorhizobium meliloti) - STRING interaction network
"bluB" - 5,6-dimethylbenzimidazole synthase in Sinorhizobium meliloti
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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bluB5,6-dimethylbenzimidazole synthase; Involved in the biosynthesis of cobalamin (vitamin B12). Catalyzes the oxidative fragmentation and contraction of the isoalloxazine heterocycle and the cleavage of the ribityl tail of FMN(2) to form 5,6-dimethylbenzimidazole (DMB) and D-erythrose 4- phosphate (E4P). NAD(P)H is only required initially to reduce FMN and oxygen drives the oxidative fragmentation; Belongs to the BluB family (227 aa)    
Predicted Functional Partners:
cobU
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5’-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (338 aa)
 
  0.995
cobB
Hydrogenobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family (429 aa)
   
  0.963
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (484 aa)
   
  0.955
cobD
Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (327 aa)
 
   
  0.922
cobO
Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (214 aa)
 
   
  0.911
SM_b20573
FMN reductase; High confidence in function and specificity (185 aa)
         
  0.906
cobC
annotation not available (333 aa)
 
   
  0.865
cobP
Bifunctional adenosylcobalamin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate; Belongs to the CobU/CobP family (175 aa)
 
   
  0.849
cobA
annotation not available (279 aa)
 
   
  0.833
cobS
Adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5’-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5’-phosphate; Belongs to the CobS family (262 aa)
 
   
  0.832
Your Current Organism:
Sinorhizobium meliloti
NCBI taxonomy Id: 266834
Other names: S. meliloti 1021, Sinorhizobium meliloti, Sinorhizobium meliloti 1021
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