node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Krad_0936 | Krad_1170 | Krad_0936 | Krad_1170 | PFAM: methylenetetrahydrofolate reductase; KEGG: art:Arth_2367 deleted entry; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: methylenetetrahydrofolate reductase; KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.924 |
Krad_0936 | folD | Krad_0936 | Krad_3980 | PFAM: methylenetetrahydrofolate reductase; KEGG: art:Arth_2367 deleted entry; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |
Krad_0936 | gcvT | Krad_0936 | Krad_4046 | PFAM: methylenetetrahydrofolate reductase; KEGG: art:Arth_2367 deleted entry; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.917 |
Krad_0936 | glyA | Krad_0936 | Krad_3981 | PFAM: methylenetetrahydrofolate reductase; KEGG: art:Arth_2367 deleted entry; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.949 |
Krad_1170 | Krad_0936 | Krad_1170 | Krad_0936 | PFAM: methylenetetrahydrofolate reductase; KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: methylenetetrahydrofolate reductase; KEGG: art:Arth_2367 deleted entry; Belongs to the methylenetetrahydrofolate reductase family. | 0.924 |
Krad_1170 | folD | Krad_1170 | Krad_3980 | PFAM: methylenetetrahydrofolate reductase; KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |
Krad_1170 | gcvT | Krad_1170 | Krad_4046 | PFAM: methylenetetrahydrofolate reductase; KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.917 |
Krad_1170 | glyA | Krad_1170 | Krad_3981 | PFAM: methylenetetrahydrofolate reductase; KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.949 |
Krad_3690 | folD | Krad_3690 | Krad_3980 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: fal:FRAAL6398 putative ligase (partial match); Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.935 |
Krad_3690 | purN | Krad_3690 | Krad_3996 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: fal:FRAAL6398 putative ligase (partial match); Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.913 |
fmt | folD | Krad_2984 | Krad_3980 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.969 |
fmt | gcvT | Krad_2984 | Krad_4046 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.946 |
fmt | glyA | Krad_2984 | Krad_3981 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.967 |
fmt | purH | Krad_2984 | Krad_3995 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: aau:AAur_1198 bifunctional purine biosynthesis protein PurH. | 0.721 |
fmt | purN | Krad_2984 | Krad_3996 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.956 |
folD | Krad_0936 | Krad_3980 | Krad_0936 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PFAM: methylenetetrahydrofolate reductase; KEGG: art:Arth_2367 deleted entry; Belongs to the methylenetetrahydrofolate reductase family. | 0.936 |
folD | Krad_1170 | Krad_3980 | Krad_1170 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PFAM: methylenetetrahydrofolate reductase; KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.936 |
folD | Krad_3690 | Krad_3980 | Krad_3690 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: fal:FRAAL6398 putative ligase (partial match); Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.935 |
folD | fmt | Krad_3980 | Krad_2984 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.969 |
folD | gcvT | Krad_3980 | Krad_4046 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |