node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
comEB | dhfR | MMOB5300 | MMOB0350 | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | Dihydrofolate reductase; COG0262; expression validated by proteogenomic mapping: 6 unique peptides covering 41.4% of sequence; Belongs to the dihydrofolate reductase family. | 0.850 |
comEB | polA | MMOB5300 | MMOB4880 | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | DNA polymerase I; COG0258; expression validated by proteogenomic mapping: 13 unique peptides covering 33.9% of sequence. | 0.443 |
comEB | tdk | MMOB5300 | MMOB6150 | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | Thymidine kinase; COG1435; expression validated by proteogenomic mapping: 5 unique peptides covering 31% of sequence. | 0.931 |
comEB | thyA | MMOB5300 | MMOB0340 | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.944 |
comEB | tmk | MMOB5300 | MMOB0760 | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.929 |
dhfR | comEB | MMOB0350 | MMOB5300 | Dihydrofolate reductase; COG0262; expression validated by proteogenomic mapping: 6 unique peptides covering 41.4% of sequence; Belongs to the dihydrofolate reductase family. | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | 0.850 |
dhfR | folD | MMOB0350 | MMOB1600 | Dihydrofolate reductase; COG0262; expression validated by proteogenomic mapping: 6 unique peptides covering 41.4% of sequence; Belongs to the dihydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.403 |
dhfR | glyA | MMOB0350 | MMOB4710 | Dihydrofolate reductase; COG0262; expression validated by proteogenomic mapping: 6 unique peptides covering 41.4% of sequence; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
dhfR | tdk | MMOB0350 | MMOB6150 | Dihydrofolate reductase; COG0262; expression validated by proteogenomic mapping: 6 unique peptides covering 41.4% of sequence; Belongs to the dihydrofolate reductase family. | Thymidine kinase; COG1435; expression validated by proteogenomic mapping: 5 unique peptides covering 31% of sequence. | 0.470 |
dhfR | thyA | MMOB0350 | MMOB0340 | Dihydrofolate reductase; COG0262; expression validated by proteogenomic mapping: 6 unique peptides covering 41.4% of sequence; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.997 |
dhfR | tmk | MMOB0350 | MMOB0760 | Dihydrofolate reductase; COG0262; expression validated by proteogenomic mapping: 6 unique peptides covering 41.4% of sequence; Belongs to the dihydrofolate reductase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.431 |
dnaN | glyA | MMOB0020 | MMOB4710 | DNA polymerase III beta chain; COG0592; expression validated by proteogenomic mapping: 18 unique peptides covering 44.2% of sequence. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.535 |
dnaN | nrdA | MMOB0020 | MMOB0160 | DNA polymerase III beta chain; COG0592; expression validated by proteogenomic mapping: 18 unique peptides covering 44.2% of sequence. | Ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.785 |
dnaN | polA | MMOB0020 | MMOB4880 | DNA polymerase III beta chain; COG0592; expression validated by proteogenomic mapping: 18 unique peptides covering 44.2% of sequence. | DNA polymerase I; COG0258; expression validated by proteogenomic mapping: 13 unique peptides covering 33.9% of sequence. | 0.999 |
dnaN | rnhB-2 | MMOB0020 | MMOB6240 | DNA polymerase III beta chain; COG0592; expression validated by proteogenomic mapping: 18 unique peptides covering 44.2% of sequence. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.957 |
dnaN | thyA | MMOB0020 | MMOB0340 | DNA polymerase III beta chain; COG0592; expression validated by proteogenomic mapping: 18 unique peptides covering 44.2% of sequence. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.759 |
folD | dhfR | MMOB1600 | MMOB0350 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Dihydrofolate reductase; COG0262; expression validated by proteogenomic mapping: 6 unique peptides covering 41.4% of sequence; Belongs to the dihydrofolate reductase family. | 0.403 |
folD | glyA | MMOB1600 | MMOB4710 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
folD | polA | MMOB1600 | MMOB4880 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | DNA polymerase I; COG0258; expression validated by proteogenomic mapping: 13 unique peptides covering 33.9% of sequence. | 0.564 |
folD | thyA | MMOB1600 | MMOB0340 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.938 |