node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMOB6160 | def | MMOB6160 | MMOB6170 | Expressed protein; Expression validated by proteogenomic mapping: 3 unique peptides covering 11.2% of sequence. | Formylmethionine deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.598 |
MMOB6160 | tdk | MMOB6160 | MMOB6150 | Expressed protein; Expression validated by proteogenomic mapping: 3 unique peptides covering 11.2% of sequence. | Thymidine kinase; COG1435; expression validated by proteogenomic mapping: 5 unique peptides covering 31% of sequence. | 0.580 |
cdd | comEB | MMOB3470 | MMOB5300 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | 0.445 |
cdd | deoA | MMOB3470 | MMOB5360 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Pyrimidine (thymidine)-nucleoside phosphorylase; COG0213; expression validated by proteogenomic mapping: 44 unique peptides covering 64.9% of sequence. | 0.953 |
cdd | deoD | MMOB3470 | MMOB5350 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Purine-nucleoside phosphorylase; COG0813; expression validated by proteogenomic mapping: 28 unique peptides covering 69.1% of sequence. | 0.950 |
cdd | pyrG | MMOB3470 | MMOB4080 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. | 0.424 |
cdd | tdk | MMOB3470 | MMOB6150 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine kinase; COG1435; expression validated by proteogenomic mapping: 5 unique peptides covering 31% of sequence. | 0.925 |
comEB | cdd | MMOB5300 | MMOB3470 | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.445 |
comEB | tdk | MMOB5300 | MMOB6150 | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | Thymidine kinase; COG1435; expression validated by proteogenomic mapping: 5 unique peptides covering 31% of sequence. | 0.931 |
comEB | thyA | MMOB5300 | MMOB0340 | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.944 |
comEB | tmk | MMOB5300 | MMOB0760 | Deoxycytidylate deaminase competance related protein; COG2131; expression validated by proteogenomic mapping: 8 unique peptides covering 51.9% of sequence. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.929 |
def | MMOB6160 | MMOB6170 | MMOB6160 | Formylmethionine deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Expressed protein; Expression validated by proteogenomic mapping: 3 unique peptides covering 11.2% of sequence. | 0.598 |
def | tdk | MMOB6170 | MMOB6150 | Formylmethionine deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Thymidine kinase; COG1435; expression validated by proteogenomic mapping: 5 unique peptides covering 31% of sequence. | 0.495 |
deoA | cdd | MMOB5360 | MMOB3470 | Pyrimidine (thymidine)-nucleoside phosphorylase; COG0213; expression validated by proteogenomic mapping: 44 unique peptides covering 64.9% of sequence. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.953 |
deoA | deoD | MMOB5360 | MMOB5350 | Pyrimidine (thymidine)-nucleoside phosphorylase; COG0213; expression validated by proteogenomic mapping: 44 unique peptides covering 64.9% of sequence. | Purine-nucleoside phosphorylase; COG0813; expression validated by proteogenomic mapping: 28 unique peptides covering 69.1% of sequence. | 0.983 |
deoA | tdk | MMOB5360 | MMOB6150 | Pyrimidine (thymidine)-nucleoside phosphorylase; COG0213; expression validated by proteogenomic mapping: 44 unique peptides covering 64.9% of sequence. | Thymidine kinase; COG1435; expression validated by proteogenomic mapping: 5 unique peptides covering 31% of sequence. | 0.937 |
deoA | thyA | MMOB5360 | MMOB0340 | Pyrimidine (thymidine)-nucleoside phosphorylase; COG0213; expression validated by proteogenomic mapping: 44 unique peptides covering 64.9% of sequence. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.430 |
deoD | cdd | MMOB5350 | MMOB3470 | Purine-nucleoside phosphorylase; COG0813; expression validated by proteogenomic mapping: 28 unique peptides covering 69.1% of sequence. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.950 |
deoD | deoA | MMOB5350 | MMOB5360 | Purine-nucleoside phosphorylase; COG0813; expression validated by proteogenomic mapping: 28 unique peptides covering 69.1% of sequence. | Pyrimidine (thymidine)-nucleoside phosphorylase; COG0213; expression validated by proteogenomic mapping: 44 unique peptides covering 64.9% of sequence. | 0.983 |
deoD | tdk | MMOB5350 | MMOB6150 | Purine-nucleoside phosphorylase; COG0813; expression validated by proteogenomic mapping: 28 unique peptides covering 69.1% of sequence. | Thymidine kinase; COG1435; expression validated by proteogenomic mapping: 5 unique peptides covering 31% of sequence. | 0.943 |